ChemicalBook > CAS DataBase List > 5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER

5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER

Product Name: 5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER
CAS No.: 64837-53-2
Chemical Name: 5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER
Synonyms: 5-aMino-1,3,4-thiadiazole-2-carboxylate;Ethyl 5-amino-1,3,4-thiadiazol-2-carboxylate;ETHYL 5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLATE;2-amino-1,3, 4-thiadiazole-5-formate ethyl ester;Ethyl 5-amino-1,3,4-thiadiazole-2-carboxylate 97%;5-Amino-1,3,4-thiadiazole-2-carboxylic acid ethyl;Ethyl 5-amino-1,3,4-thiadiazole-2-carboxylate ,97%;5-AMino-1,3,4-thiadiazol-2-carboxylic acid ethyl ester;5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER;1,3,4-Thiadiazole-2-carboxylicacid, 5-aMino-, ethyl ester
CBNumber: CB2206024
Molecular Formula: C5H7N3O2S
Formula Weight: 173.19
MOL File: 64837-53-2.mol

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5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER Property

Melting point:: 197-199°C
Boiling point:: 317.9±25.0 °C(Predicted)
Density: 1.419±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
form: powder
pka: 0.82±0.10(Predicted)
color: Dark yellow
InChI: InChI=1S/C5H7N3O2S/c1-2-10-4(9)3-7-8-5(6)11-3/h2H2,1H3,(H2,6,8)
InChIKey: YVKRWIVXIPGKTL-UHFFFAOYSA-N
SMILES: S1C(N)=NN=C1C(OCC)=O

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: E899323
Product name: Ethyl5-amino-1,3,4-thiadiazole-2-carboxylate
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Oakwood

Product number: 005972
Product name: 5-Amino-1,3,4-thiadiazole-2-carboxylicacidethylester
Purity: 97%
Packaging: 5g
Price: $59
Updated: 2021/12/16

Matrix Scientific

Product number: 119358
Product name: Ethyl 5-amino-1,3,4-thiadiazole-2-carboxylate
Purity: 95+%
Packaging: 1g
Price: $65
Updated: 2021/12/16

Oakwood

Product number: 005972
Product name: 5-Amino-1,3,4-thiadiazole-2-carboxylicacidethylester
Purity: 97%
Packaging: 1g
Price: $14
Updated: 2021/12/16

AK Scientific

Product number: J51011
Product name: Ethyl5-amino-1,3,4-thiadiazole-2-carboxylate
Packaging: 1g
Price: $15
Updated: 2021/12/16

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5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Synthesis

79-19-6

4755-77-5

64837-53-2

Step 1: Synthesis of ethyl 5-amino-1,3,4-thiadiazole-2-carboxylate Hydrazinothioformamide (10 g, 54.8 mmol) was dissolved in phosphorus trichloride (25 mL) followed by addition of ethyl 2-chloro-2-oxoacetate (6.1 mL, 54.8 mmol). The reaction mixture was heated to 70 °C and stirred continuously for 5 hours. Upon completion of the reaction, phosphorous trichloride was completely evaporated under reduced pressure. The residue was diluted with ice water (150 mL) and the pH was adjusted with saturated sodium bicarbonate solution to 8. Subsequently, the mixture was extracted with ethyl acetate (200 mL). The organic layer was separated, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography (silica gel 100-200 mesh, eluent 2% methanol/dichloromethane) to afford ethyl 5-amino-1,3,4-thiadiazole-2-carboxylate as a yellow solid (3.1 g, 24% yield). 1H NMR (400 MHz, DMSO-d6) δ: 7.94 (s, 2H), 4.29 (q, 2H), 1.27 (t, 3H); LC-MS m/z calculated value [M + H]+ 174.03, measured value 174.1.

References

[1] Patent: WO2013/49565, 2013, A1. Location in patent: Page/Page column 68
[2] Annali di Chimica (Rome, Italy), 1959, vol. 49, p. 2124,2131
[3] Patent: WO2007/38865, 2007, A1. Location in patent: Page/Page column 47

5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

thiosemicarbazide Ethanol Sodium sulfate Ethyl glyoxalate Ferric chloride Acetic acid

Preparation Products

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View Lastest Price from 5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER 64837-53-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

Shaanxi Dideu New Materials Co. Ltd

Product: 5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER 64837-53-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-03-19

Career Henan Chemical Co

Product: 5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER 64837-53-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 200kg
Release date: 2019-08-30

64837-53-2, 5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTERRelated Search:

1,3,4-Thiadiazole, 2-amino-5-(mercaptomethyl)- (8CI) (5-Amino-1,3,4-thiadiazol-2-yl)methanol 2-Amino-1,3,4-thiadiazole 5-AMINO-1,2,3-THIADIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 5-AMINO-[1,3,4]THIADIAZOLE-2-CARBALDEHYDE 1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID,97% 5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER

ETHYL 5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLATE

5-AMINO-1,3,4-THIADIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER

5-AMino-1,3,4-thiadiazol-2-carboxylic acid ethyl ester

5-Amino-1,3,4-thiadiazole-2-carboxylic acid ethyl

Ethyl 5-amino-1,3,4-thiadiazole-2-carboxylate ,97%

1,3,4-Thiadiazole-2-carboxylicacid, 5-aMino-, ethyl ester

5-aMino-1,3,4-thiadiazole-2-carboxylate

Ethyl 5-amino-1,3,4-thiadiazole-2-carboxylate 97%

2-amino-1,3, 4-thiadiazole-5-formate ethyl ester

1,3,4-Thiadiazole-2-carboxylic acid, 5-amino-, ethyl ester (6CI, 7CI, 9CI, ACI)

5-amino-1,3,4-Thiadiazole-2-carboxylic acid ethyl ester (6CI 7CI 9CI ACI)

Ethyl 5-amino-1,3,4-thiadiazol-2-carboxylate

64837-53-2

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