ChemicalBook > CAS DataBase List > CHLOROMETHYL PHENYL SULFONE

CHLOROMETHYL PHENYL SULFONE

Product Name: CHLOROMETHYL PHENYL SULFONE
CAS No.: 7205-98-3
Chemical Name: CHLOROMETHYL PHENYL SULFONE
Synonyms: Ai3-09778;Einecs 230-581-8;CHLOROMETHYL PHENYL;CHLOROMETHYL PHENYL SULFONE;PHENYL CHLOROMETHYL SULFONE;2-ChloroMethylphenylsulfone;chloromethyl phenyl sulphone;(Phenylsulfonyl)chloromethane;Phenylsulfonylmethyl chloride;[(CHLOROMETHYL)SULFONYL]BENZENE
CBNumber: CB2210252
Molecular Formula: C7H7ClO2S
Formula Weight: 190.65
MOL File: 7205-98-3.mol

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CHLOROMETHYL PHENYL SULFONE Property

Melting point:: 51-53 °C (lit.)
Boiling point:: 130 °C / 1mmHg
Density: 1.336±0.06 g/cm3(Predicted)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
color: White to Almost white
BRN: 2046644
InChIKey: NXAIQSVCXQZNRY-UHFFFAOYSA-N
CAS DataBase Reference: 7205-98-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 21
HS Code: 29049095

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 324604
Product name: Chloromethyl phenyl sulfone
Purity: ≥97%
Packaging: 5g
Price: $61.1
Updated: 2023/06/20

TCI Chemical

Product number: C1571
Product name: Chloromethyl Phenyl Sulfone
Purity: >98.0%(GC)
Packaging: 5g
Price: $135
Updated: 2025/07/31

TCI Chemical

Product number: C1571
Product name: Chloromethyl Phenyl Sulfone
Purity: >98.0%(GC)
Packaging: 25g
Price: $441
Updated: 2025/07/31

TRC

Product number: C587935
Product name: Chloromethyl Phenyl Sulfone
Packaging: 100mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: J97755
Product name: Chloromethyl Phenyl Sulfone
Packaging: 1g
Price: $25
Updated: 2021/12/16

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CHLOROMETHYL PHENYL SULFONE Chemical Properties,Usage,Production

Uses

Chloromethyl Phenyl Sulfone is used to synthesis of α,β-epoxy sulfones and aziridines; reacts with electrophilic arenes, heterocyclic arenes, and alkenes; source of the α-phenylsulfonylmethyl radical.

Preparation

Preparative Methods of Chloromethyl Phenyl Sulfone: several methods are available. The most convenient is the reaction of Sodium Benzenesulfinate dihydrate with bromochloromethane in dimethyl sulfoxide.

Synthesis

100-68-5

3112-85-4

7205-98-3

The general procedure for the synthesis of phenylmethyl sulfone and chloromethyl phenyl sulfone from methyl phenyl sulfide was as follows: 0.25 g (2 mmol) of methyl phenyl sulfide was used as a substrate and added to a 50 mL three-necked flask along with 10 mL of acetonitrile and 2 mL of water. The internal temperature of the flask was maintained at 23 °C. Subsequently, 0.09 g (4.8 mmol) of sodium hypochlorite pentahydrate crystals were added in portions with continuous stirring. During the reaction, the internal temperature of the flask was increased to 28°C and then gradually decreased. GC analysis was performed 3 h after the start of the reaction and showed that 22% of the methyl phenyl sulfide was converted to methyl phenyl sulfoxide and 65% to methyl phenyl sulfone. By-products included 6% chloromethyl phenyl sulfoxide and 7% chloromethyl phenyl sulfone, and a total of 0.8% advanced chlorides. Addition of 0.79 g (4.8 mmol) of sodium hypochlorite pentahydrate crystals was continued and stirring was continued for 1 hour. At this point, the methyl phenyl sulfide and methyl phenyl sulfoxide completely disappeared and the yield of methyl phenyl sulfone increased to 87%. Impurities included 11% chloromethyl phenyl sulfone, 0.5% dichloromethyl phenyl sulfone and 1.3% trichloromethyl phenyl sulfone.

Solubility in organics

Chloromethyl Phenyl Sulfone is soluble in THF, CHCl3, CH2Cl2, and most organic solvents.

References

[1] Patent: JP2017/52730, 2017, A. Location in patent: Paragraph 0046

CHLOROMETHYL PHENYL SULFONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CHLOROMETHYL PHENYL SULFONE manufacturers

Career Henan Chemical Co

Product: CHLOROMETHYL PHENYL SULFONE 7205-98-3
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

7205-98-3, CHLOROMETHYL PHENYL SULFONERelated Search:

TRANS-1,2-BIS(PHENYLSULFONYL)ETHYLENE 1-CHLORO-2-PHENYLVINYL 4-METHYLPHENYL SULFONE 4-[2-CHLORO-2-(PHENYLSULFONYL)ETHYL]-1,4-OXAZINAN-4-IUM CHLORIDE CHLOROMETHYL PHENYL SULFONE 3,5-BIS(TRIFLUOROMETHYL)PHENYL CHLOROMETHYL SULFONE 1,2-DICHLOROVINYL4-METHYLPHENYLSULFONE 1-chloro-4-[(chloromethyl)sulphonyl]benzene 1-[(CHLOROMETHYL)SULFONYL]NAPHTHALENE P-TOLUENESULFONYLMETHYL CHLORIDE

PHENYL CHLOROMETHYL SULFONE

CHLOROMETHYL PHENYL SULFONE

[(CHLOROMETHYL)SULFONYL]BENZENE

[(chloromethyl)sulphonyl]benzene

chloromethyl phenyl sulphone

Ai3-09778

Benzene, ((chloromethyl)sulfonyl)-

Einecs 230-581-8

1-(Chloromethylsulfonyl)benzene

CHLOROMETHYL PHENYL

(Phenylsulfonyl)chloromethane

Phenylsulfonylmethyl chloride

2-ChloroMethylphenylsulfone

Chloromethyl Phenyl Sulfone &gt

7205-98-3

C6H5SO2CH2Cl

Organic Building Blocks

Sulfur Compounds

Sulfones

Building Blocks

Organic Building Blocks

Sulfones

Sulfur Compounds