PHE-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-ARG-LYS-ASN-GLN
- Product Name
- PHE-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-ARG-LYS-ASN-GLN
- CAS No.
- 236098-40-1
- Chemical Name
- PHE-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-ARG-LYS-ASN-GLN
- Synonyms
- [ARG14,LYS15]NOCICEPTIN;[ARG14,LYS15] ORPHANIN FQ;[ARG14, LYS15]NOCICEPTIN/ORPHANIN FQ;PHE-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-ARG-LYS-ASN-GLN;L-Glutamine, L-phenylalanylglycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-arginyl-L-lysyl-L-asparaginyl-
- CBNumber
- CB2210515
- Molecular Formula
- C82H137N31O22
- Formula Weight
- 1909.16
- MOL File
- 236098-40-1.mol
PHE-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-ARG-LYS-ASN-GLN Property
- storage temp.
- 2-8°C
- form
- solid
- color
- white
- Water Solubility
- Soluble to 1 mg/ml in water
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 254666
- Product name
- [Arg14,Lys15]Nociceptin
- Packaging
- 1mg
- Price
- $516
- Updated
- 2021/12/16
- Product number
- B5136
- Product name
- [Arg14,Lys15]Nociceptin
- Packaging
- 1mg
- Price
- $377
- Updated
- 2021/12/16
- Product number
- PEP0003901
- Product name
- [ARG14,LYS15]NOCICEPTIN
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $646.4
- Updated
- 2021/12/16
- Product number
- PEP0003901
- Product name
- [ARG14,LYS15]NOCICEPTIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $990.99
- Updated
- 2021/12/16
PHE-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-ARG-LYS-ASN-GLN Chemical Properties,Usage,Production
Uses
[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively[1].
in vivo
In in vivo experiments, [Arg14,Lys15]Nociceptin mimics the effects of NC, producing, after intracerebroventricular administration, pronociceptive effects in the tail-withdrawal assay and inhibiting the locomotor activity of the mice[2].
References
[1] Okada K, Sujaku T, Chuman Y, et al. Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem Biophys Res Commun. 2000;278(2):493-498. DOI:10.1006/bbrc.2000.3822
[2] Rizzi D, Rizzi A, Bigoni R, et al. [Arg(14),Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J Pharmacol Exp Ther. 2002;300(1):57-63. DOI:10.1124/jpet.300.1.57
PHE-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-ARG-LYS-ASN-GLN Preparation Products And Raw materials
Raw materials
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