8-Trifluoromethyl-chroman-4-one
- Product Name
- 8-Trifluoromethyl-chroman-4-one
- CAS No.
- 890839-66-4
- Chemical Name
- 8-Trifluoromethyl-chroman-4-one
- Synonyms
- 8-(Trifluoromethyl);8-Trifluoromethyl-chroman-4-one;2,3-Dihydro-8-(trifluoromethyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-8-(trifluoromethyl)-
- CBNumber
- CB22105851
- Molecular Formula
- C10H7F3O2
- Formula Weight
- 216.16
- MOL File
- 890839-66-4.mol
8-Trifluoromethyl-chroman-4-one Property
- Boiling point:
- 288℃
- Density
- 1.374
- Flash point:
- 124℃
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2934999090
N-Bromosuccinimide Price
- Product number
- PC201364
- Product name
- 8-(Trifluoromethyl)chroman-4-one
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 2H17-3-0A
- Product name
- 8-(Trifluoromethyl)chroman-4-one
- Purity
- 95.0%
- Packaging
- 100mg
- Price
- $136
- Updated
- 2021/12/16
- Product number
- PC201364
- Product name
- 8-(Trifluoromethyl)chroman-4-one
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $136
- Updated
- 2021/12/16
- Product number
- 2H17-3-0A
- Product name
- 8-(Trifluoromethyl)chroman-4-one
- Purity
- 95.0%
- Packaging
- 250mg
- Price
- $218
- Updated
- 2021/12/16
- Product number
- HCH0044797
- Product name
- 8-TRIFLUOROMETHYL-CHROMAN-4-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.06
- Updated
- 2021/12/16
8-Trifluoromethyl-chroman-4-one Chemical Properties,Usage,Production
Synthesis
890839-64-2
890839-66-4
General procedure for the synthesis of 8-trifluoromethylbenzodihydropyran-4-one using the compound (CAS: 890839-64-2) as starting material: a mixed solution of Example 18A (24.1 g, 103 mmol) with sulfuric acid (12 mL, 225 mmol) in 200 mL of trifluoroacetic acid was stirred at room temperature for 3 days. Upon completion of the reaction, the reaction mixture was slowly poured into ice water and extracted with dichloromethane (2 x 200 mL). The organic phases were combined and washed with 200 mL of saturated aqueous sodium bicarbonate followed by drying with anhydrous magnesium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure. Purification by silica gel column chromatography (eluent: 15% ethyl acetate/hexane) afforded the target product 8-trifluoromethylbenzodihydropyran-4-one (7.21 g, 33.4 mmol, 32% yield). Mass spectrum (DC1/NH3) m/z 216 (M + NH4 - H2O)+.
References
[1] Patent: US2013/158067, 2013, A1. Location in patent: Paragraph 0378
[2] Patent: WO2012/139775, 2012, A1. Location in patent: Page/Page column 59
[3] Patent: US2006/128689, 2006, A1. Location in patent: Page/Page column 25
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 5, p. 1338 - 1341
8-Trifluoromethyl-chroman-4-one Preparation Products And Raw materials
Raw materials
Preparation Products
8-Trifluoromethyl-chroman-4-one Suppliers
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 010-56330744 18310155299
- Fax
- 010-56330744
- sales@labter.com.cn
- Country
- China
- ProdList
- 20000
- Advantage
- 55
- Tel
- 86-(0)21-31261262 373522135
- Fax
- 86-(0)21-33250524
- sales@novochemy.com
- Country
- China
- ProdList
- 6498
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 13062833949; 4006653949 4006653949
- Fax
- QQ: 2136646215
- fred.wen@crcorporation.cn
- Country
- China
- ProdList
- 9755
- Advantage
- 58
- Tel
- 029-86115547 17791676824
- Fax
- 021-51602123
- sales@cochemical.com
- Country
- China
- ProdList
- 4006
- Advantage
- 58
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15814
- Advantage
- 58
- Tel
- 13331045123
- Fax
- 86-10-80339217
- 2559355526@qq.com
- Country
- China
- ProdList
- 14193
- Advantage
- 58
- Tel
- 0512-65816829 18662214788
- Fax
- 0512-65816829
- info@rovathin.com.cn
- Country
- China
- ProdList
- 9987
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- 19903857099
- Fax
- QQ: 2865126155
- sales@graybio.com
- Country
- China
- ProdList
- 2955
- Advantage
- 58
- Tel
- 0371-0371-53736046 13393710386
- Fax
- QQ:2853979814
- 2853979814@qq.com
- Country
- China
- ProdList
- 9948
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39653
- Advantage
- 58
- Tel
- 19131160546
- 2681315246@qq.com
- Country
- China
- ProdList
- 13199
- Advantage
- 58
- Tel
- 029-029-81148929 17791530722
- 1049@dideu.com
- Country
- China
- ProdList
- 10011
- Advantage
- 58
- Tel
- 17734807184; 17734807184
- 3805691809@qq.com
- Country
- China
- ProdList
- 6433
- Advantage
- 58
- Tel
- +86-88938639 +86-17705817739
- info@dycnchem.com
- Country
- China
- ProdList
- 53899
- Advantage
- 58
- Tel
- +86-571-87711850
- market18@leapchem.com
- Country
- China
- ProdList
- 43339
- Advantage
- 58
- Tel
- +undefined18958062155
- sales@zjgoldpharm.com
- Country
- China
- ProdList
- 5899
- Advantage
- 58
- Tel
- 15902098758
- Country
- CHINA
- ProdList
- 133
- Advantage
- 58