2-bromo-N-isopropylacetamide
- Product Name
- 2-bromo-N-isopropylacetamide
- CAS No.
- 75726-96-4
- Chemical Name
- 2-bromo-N-isopropylacetamide
- Synonyms
- 2-broMo-N-(propan-2-yl)acetaMide;Belumosudil Impurity 8;Belumosudil Impurity 26;2-Bromo-N-isopropylamide;2-bromo-N-isopropylacetamide;N-(Bromoacetyl)isopropylamine;2-Bromo-N-(1-methylethyl)-acetamide;acetamide, 2-bromo-N-(1-methylethyl)-;2-bromo-N-isopropylacetamide - [AC80036];2-bromo-N-isopropylacetamide(SALTDATA: FREE)
- CBNumber
- CB22110501
- Molecular Formula
- C5H10BrNO
- Formula Weight
- 180.04
- MOL File
- 75726-96-4.mol
2-bromo-N-isopropylacetamide Property
- Melting point:
- 63-64℃
- Boiling point:
- 266℃
- Density
- 1.378
- Flash point:
- 115℃
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 13.71±0.46(Predicted)
- InChI
- InChI=1S/C5H10BrNO/c1-4(2)7-5(8)3-6/h4H,3H2,1-2H3,(H,7,8)
- InChIKey
- ZLDCRYWMEQJDGW-UHFFFAOYSA-N
- SMILES
- C(NC(C)C)(=O)CBr
Safety
- HazardClass
- IRRITANT
- HS Code
- 2924297099
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B695305
- Product name
- 2-Bromo-N-isopropylacetamide
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B695305
- Product name
- 2-Bromo-N-isopropylacetamide
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- FB121688
- Product name
- 2-Bromo-N-isopropylacetamide
- Packaging
- 5G
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 1764AC
- Product name
- 2-Bromo-N-isopropylacetamide
- Packaging
- 1g
- Price
- $127
- Updated
- 2021/12/16
- Product number
- FB121688
- Product name
- 2-Bromo-N-isopropylacetamide
- Packaging
- 2g
- Price
- $80
- Updated
- 2021/12/16
2-bromo-N-isopropylacetamide Chemical Properties,Usage,Production
Uses
2-Bromo-N-isopropylacetamide is a an intermediate of Belumosudil.
Synthesis
75-31-0
598-21-0
75726-96-4
Dichloromethane (5 mL) and isopropylamine (1.2 mmol) were added to a 25 mL round-bottomed flask, corked tightly and protected under a nitrogen atmosphere. Bromoacetyl bromide (1 mmol) was slowly added dropwise over 2 min under ice bath cooling and stirring conditions. After the dropwise addition, the reaction was continued in an ice bath for 5 min, after which the reaction mixture was transferred to room temperature and stirred for 1 hr. The progress of the reaction was monitored by thin layer chromatography (TLC) until the complete disappearance of bromoacetyl bromide. Upon completion of the reaction, the resulting white solid was collected by filtration and washed with dichloromethane. The filtrate and washings were combined, and the organic layer was sequentially extracted with dilute hydrochloric acid solution, dichloromethane, washed with saturated brine and dried with anhydrous Na2SO4. After concentration under reduced pressure to remove the solvent, the target compound 2-bromo-N-isopropylacetamide was purified by column chromatography to afford the target compound as a white solid in 71% yield.
References
[1] Journal of the American Chemical Society, 2006, vol. 128, # 48, p. 15476 - 15489
[2] Patent: CN106916145, 2017, A. Location in patent: Paragraph 0017; 0035-0038; 0058; 0066
[3] Patent: WO2008/54599, 2008, A2. Location in patent: Page/Page column 152
[4] Patent: WO2010/104851, 2010, A1. Location in patent: Page/Page column 147; 148
[5] Patent: WO2014/55999, 2014, A2. Location in patent: Paragraph 0164
2-bromo-N-isopropylacetamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-bromo-N-isopropylacetamide manufacturers
- Product
- 2-Bromo-N-isopropylacetamide 75726-96-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-25
- Product
- 2-bromo-N-isopropylacetamide in stock Factory 75726-96-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- TOP 3 Factory in China
- Supply Ability
- Top 3 largest production capacity Factory
- Release date
- 2019-04-03
- Product
- 2-bromo-N-isopropylacetamide 75726-96-4
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-20