1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride
- Product Name
- 1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride
- CAS No.
- 203911-27-7
- Chemical Name
- 1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride
- Synonyms
- HA-1077 (hydrochloride);HA-1077 dihydrochloride solid, >=98% (HPLC);Isoquinoline, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:2);1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride;1-(5-Isoquinolinesulphonyl)homopiperazine dihydrochloride salt, Fausidil dihydrochoride salt;HA-1077 dihydrochloride,1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride
- CBNumber
- CB22129608
- Molecular Formula
- C14H17N3O2S.2ClH.H2O
- Formula Weight
- 382.31
- MOL File
- 203911-27-7.mol
1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride Property
- Density
- 1.289
- RTECS
- HM4031166
- Flash point:
- 260℃
- storage temp.
- Store at -20°C
- solubility
- H2O: >10mg/mL
- form
- solid
- color
- white to off-white
- Water Solubility
- Soluble in water and dimethylsulfoxide.
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- H139
- Product name
- HA-1077 dihydrochloride
- Purity
- solid, ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $403
- Updated
- 2024/03/01
- Product number
- H139
- Product name
- HA-1077 dihydrochloride
- Purity
- solid, ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $631
- Updated
- 2024/03/01
- Product number
- J60594
- Product name
- Fasudil dihydrochloride, 99+%
- Packaging
- 250mg
- Price
- $187.65
- Updated
- 2024/03/01
- Product number
- J60594
- Product name
- Fasudil dihydrochloride, 99+%
- Packaging
- 1g
- Price
- $632.65
- Updated
- 2024/03/01
- Product number
- 10010559
- Product name
- HA-1077 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $44
- Updated
- 2024/03/01
1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride Chemical Properties,Usage,Production
Description
Rho-associated kinase (ROCK), an effector of the small GTP-binding protein Rho, plays an important role in various cellular functions including vascular smooth muscle contraction, proliferation, and migration as well as inflammatory cell mobility. HA-1077 is a potent inhibitor of ROCK2 and additionally inhibits protein kinase c-related kinase 2 (PRK2), mitogen- and stress-activated protein kinase (MSK1), and mitogen activated protein kinase-activated protein kinase 1b (MAPKAP-K1b) with IC50 values of 1.9, 4, 5, and 15 μM, respectively. By inhibiting the activity of ROCK, HA-1077 has been shown to reduce blood vessel constriction, decrease pulmonary arterial pressure, inhibit tumor angiogenesis, and improve insulin signaling in various rodent models. While originally marketed for the prevention of cerebral vasospasm in patients with subarachnoid hemorrhage, oral formulations of HA-1077 are used for the treatment of a wide range of cardiovascular diseases including pulmonary arterial hypertension and stable angina.
Chemical Properties
White fine crystalline powder
Uses
Fasudil dihydrochloride is used in the inhibition of contractile responses to potassium chloride, phenylephnne (PHE), prostaglandin and hepatic stellate cells spreading. It is also used in the formation of stress fibers and in medicine.
Uses
HA-1077 dihydrochloride has been used:
- to relax cantilevers
- in the functional assessment of isolated coronary arteries
- to investigate the effect of azaindole-1, fasudil on acute hypoxic pulmonary vasoconstriction (HPV)
Biochem/physiol Actions
Novel vasodilator agent which inhibits vascular smooth muscle contraction by acting as an intracellular Ca2+ antagonist.
1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride manufacturers
- Product
- 1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride 203911-27-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10