3，5-dimethyl-Tricyclo[3.3.1.13,7]decan-1-amine
- Product Name
- 3，5-dimethyl-Tricyclo[3.3.1.13,7]decan-1-amine
- CAS No.
- 51052-62-1
- Chemical Name
- 3，5-dimethyl-Tricyclo[3.3.1.13,7]decan-1-amine
- Synonyms
- Memantine Hydrochloride Impurity
- CBNumber
- CB22130921
- Molecular Formula
- C12H21N
- Formula Weight
- 179.30184
- MOL File
- 51052-62-1.mol
3，5-dimethyl-Tricyclo[3.3.1.13,7]decan-1-amine Property
- Melting point:
- 118-119℃
- Boiling point:
- 395.9°C at 760 mmHg
- Density
- 1.168g/cm3
- vapor pressure
- 1.78E-06mmHg at 25°C
- refractive index
- 1.518
- Flash point:
- 193.2°C
- storage temp.
- -20℃
- solubility
- Soluble in water (34 mg/ml at 25 °C), DMSO (34 mg/ml at 25 °C), and ethanol (34 mg/
- form
- crystalline powder
- color
- White
3，5-dimethyl-Tricyclo[3.3.1.13,7]decan-1-amine Chemical Properties,Usage,Production
Description
Memantine, a NMDA receptor antagonist, was co-developed by Forest Laboratories with Merz Pharmaceuticals and marketed under the trade name Namenda for the treatment of Alzheimer’s disease in the US after its approval in October, 2003. This drug has been available in many European and Asian markets before getting approval in the US.
Chemical Properties
White crystalline powder
in vitro
Memantine（3，5-dimethyl-Tricyclo[3.3.1.13,7]decan-1-amine） is an NMDA receptor antagonist that blocks NMDA-induced currents in rat retinal ganglion cells by 90% when used at a concentration of 12 μM. It reverses inhibition of dephosphorylation of the synthetic tau phosphopeptide p17 (tau194-207) induced by the endogenous inhibitor of protein phosphatase 2A (PP2A) I1PP2A in vitro.
in vivo
In vivo, memantine (2 mg/kg) restores PP2A activity, decreases GSK-3β and amyloid-β (Aβ) levels in the hippocampus, cerebral cortex, and ventricular areas, and attenuates spatial learning and memory in the AAV1-I1PP2A rat model of Alzheimer''s disease. Memantine (20 mg/kg) reduces responding on the ethanol-associated lever in a cue-induced ethanol-seeking test in rats. It also decreases secretion of matrix metalloproteinase-9 (MMP-9), degradation of collagen IV, the size of cerebral ischemia-induced brain infarcts, and neuronal cell death in a mouse model of focal cerebral ischemia.
3，5-dimethyl-Tricyclo[3.3.1.13,7]decan-1-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3，5-dimethyl-Tricyclo[3.3.1.13,7]decan-1-amine manufacturers
- Product
- Memantine hydrochloride 51052-62-1
- Price
- US $603.00/KG
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2021-06-04