9H-Cyclohepta[a]naphthalen-9-one,1,2,3,4- tetrahydro-10-hydroxy-4,4,8-trimethyl-
- Product Name
- 9H-Cyclohepta[a]naphthalen-9-one,1,2,3,4- tetrahydro-10-hydroxy-4,4,8-trimethyl-
- CAS No.
- 119400-86-1
- Chemical Name
- 9H-Cyclohepta[a]naphthalen-9-one,1,2,3,4- tetrahydro-10-hydroxy-4,4,8-trimethyl-
- Synonyms
- Salviolone;Salvianolone;1,2,3,4-Tetrahydro-10-hydroxy-4,4,8-trimethyl-9H-cyclohepta[a]naphthalen-9-one;9H-Cyclohepta[a]naphthalen-9-one,1,2,3,4- tetrahydro-10-hydroxy-4,4,8-trimethyl-;9H-Cyclohepta[a]naphthalen-9-one,1,2,3,4- tetrahydro-10-hydroxy-4,4,8-trimethyl- USP/EP/BP
- CBNumber
- CB22131317
- Molecular Formula
- C18H20O2
- Formula Weight
- 268.35
- MOL File
- 119400-86-1.mol
9H-Cyclohepta[a]naphthalen-9-one,1,2,3,4- tetrahydro-10-hydroxy-4,4,8-trimethyl- Property
- Melting point:
- 180-182 °C
- Boiling point:
- 461.2±45.0 °C(Predicted)
- Density
- 1.140±0.06 g/cm3(Predicted)
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- cryst.
- pka
- 7.94±0.40(Predicted)
- color
- Yellow
N-Bromosuccinimide Price
- Product number
- CFN92163
- Product name
- Salviolone
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $595
- Updated
- 2021/12/16
9H-Cyclohepta[a]naphthalen-9-one,1,2,3,4- tetrahydro-10-hydroxy-4,4,8-trimethyl- Chemical Properties,Usage,Production
Uses
Salviolone is a natural diterpenoid derivative that can against melanoma cells. Salviolone exhibits a pleiotropic effect against melanoma by hampering cell cycle progression, STAT3 signaling, and malignant phenotype of A375 melanoma cells[1].
Synthesis
9H-Cyclohepta[a]naphthalen-9-one,1,2,3,4- tetrahydro-10-hydroxy-4,4,8-trimethyl- is prepared as follows: 10kg of crude powder of Salvia miltiorrhiza root was extracted with 95% ethanol by ultrasonication for 3 times, the extract was combined, and the extract was recovered to be free of alcoholic flavor, and the extract was pinched and dissolved with appropriate amount of water, and extracted with ethyl acetate, and the extract was obtained as 87g.The extract was separated by repeated silica gel column chromatography, and the compounds to were obtained by recrystallization. Compound III is Salvia miltiorrhiza phenolone,
References
[1] Valentina Zanrè, et al. Salviolone from Salvia miltiorrhiza Roots Impairs Cell Cycle Progression, Colony Formation, and Metalloproteinase-2 Activity in A375 Melanoma Cells: Involvement of P21(Cip1/Waf1) Expression and STAT3 Phosphorylation. Int J Mol Sci. 2022 Jan 20;23(3):1121. DOI:10.3390/ijms23031121
9H-Cyclohepta[a]naphthalen-9-one,1,2,3,4- tetrahydro-10-hydroxy-4,4,8-trimethyl- Preparation Products And Raw materials
Raw materials
Preparation Products
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