31C
- Product Name
- 31C
- CAS No.
- 398515-96-3
- Chemical Name
- 31C
- Synonyms
- 31C;III-31-C;WPE-III-31C;III-31-C >=98% (HPLC), solid;GAMMA-SECRETASE INHIBITOR XVII;N-[[[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl](phenylmethyl)amino]carbonyl]-L-leucyl-L-valine methyl ester;L-Valine, N-[[[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl](phenylmethyl)amino]carbonyl]-L-leucyl-, methyl ester
- CBNumber
- CB2214270
- Molecular Formula
- C35H52N4O7
- Formula Weight
- 640.81
- MOL File
- 398515-96-3.mol
31C Property
- Boiling point:
- 832.6±65.0 °C(Predicted)
- Density
- 1.135±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: ≥9mg/mL
- form
- solid
- pka
- 12.04±0.46(Predicted)
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- C0619
- Product name
- III-31-C
- Purity
- ≥98% (HPLC), solid
- Packaging
- 1mg
- Price
- $122
- Updated
- 2025/07/31
- Product number
- C0619
- Product name
- III-31-C
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $356
- Updated
- 2025/07/31
31C Chemical Properties,Usage,Production
Uses
III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor. III-31-C inhibits A? production with an IC50 of 10 nM in the cell-free γ-secretase assay and 200 nM in APP-transfected cells. III-31-C can be used in Alzheimer's disease research[1].
Biological Activity
III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor th at binds to γ-secretase at the substrate docking site. DAPT, also a γ-secretase inhibitor binds to the substrate docking site as well. III-31-C is useful for the affinity isolation and characterization of the protease complex and for testing other ihhibitors th at affect the γ-secretase active site. The γ-secretase complex is composed of presenilin as a catalytic component and three integral membrane proteins, nicastrin, Aph-1 and Pen-2.
References
[1] Kornilova AY, et al. Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications. J Biol Chem. 2003 May 9;278(19):16470-3. DOI:10.1074/jbc.C300019200
31C Preparation Products And Raw materials
Raw materials
Preparation Products
31C Suppliers
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