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31C

Product Name
31C
CAS No.
398515-96-3
Chemical Name
31C
Synonyms
31C;III-31-C;WPE-III-31C;III-31-C >=98% (HPLC), solid;GAMMA-SECRETASE INHIBITOR XVII;N-[[[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl](phenylmethyl)amino]carbonyl]-L-leucyl-L-valine methyl ester;L-Valine, N-[[[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl](phenylmethyl)amino]carbonyl]-L-leucyl-, methyl ester
CBNumber
CB2214270
Molecular Formula
C35H52N4O7
Formula Weight
640.81
MOL File
398515-96-3.mol
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31C Property

Boiling point:
832.6±65.0 °C(Predicted)
Density 
1.135±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: ≥9mg/mL
form 
solid
pka
12.04±0.46(Predicted)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C0619
Product name
III-31-C
Purity
≥98% (HPLC), solid
Packaging
1mg
Price
$122
Updated
2025/07/31
Sigma-Aldrich
Product number
C0619
Product name
III-31-C
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$356
Updated
2025/07/31
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31C Chemical Properties,Usage,Production

Uses

III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor. III-31-C inhibits A? production with an IC50 of 10 nM in the cell-free γ-secretase assay and 200 nM in APP-transfected cells. III-31-C can be used in Alzheimer's disease research[1].

Biological Activity

III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor th at binds to γ-secretase at the substrate docking site. DAPT, also a γ-secretase inhibitor binds to the substrate docking site as well. III-31-C is useful for the affinity isolation and characterization of the protease complex and for testing other ihhibitors th at affect the γ-secretase active site. The γ-secretase complex is composed of presenilin as a catalytic component and three integral membrane proteins, nicastrin, Aph-1 and Pen-2.

References

[1] Kornilova AY, et al. Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications. J Biol Chem. 2003 May 9;278(19):16470-3. DOI:10.1074/jbc.C300019200

31C Preparation Products And Raw materials

Raw materials

Preparation Products

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31C Suppliers

China 3 United States 2 Global 5
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
EMD Biosciences, Inc.
Tel
--
Fax
--
Email
technical@calbiochem.com
Country
United States
ProdList
6529
Advantage
66

398515-96-3, 31CRelated Search:

GAMMA-SECRETASE INHIBITOR

  • WPE-III-31C
  • GAMMA-SECRETASE INHIBITOR XVII
  • 31C
  • III-31-C
  • N-[[[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl](phenylmethyl)amino]carbonyl]-L-leucyl-L-valine methyl ester
  • L-Valine, N-[[[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl](phenylmethyl)amino]carbonyl]-L-leucyl-, methyl ester
  • III-31-C >=98% (HPLC), solid
  • 398515-96-3
  • C35H52N4O7