ChemicalBook > CAS DataBase List > J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone

J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone

Product Name
J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone
CAS No.
16265-56-8
Chemical Name
J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone
Synonyms
6-Deoxyjacareubin;6-Desoxyjacareubin;6-Dehydroxyjacareubin;9-Deshydroxyjacareubin;5,10-dihydroxy-2,2-dimethylpyrano[3,2-b]xanthen-6-one;5,10-Dihydroxy-2,2-dimethyl-2H,6H-pyrano[3,2-b]xanthen-6-one;2H,6H-Pyrano[3,2-b]xanthen-6-one, 5,10-dihydroxy-2,2-dimethyl-;J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone
CBNumber
CB22196365
Molecular Formula
C18H14O5
Formula Weight
310.3
MOL File
16265-56-8.mol
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J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone Property

Melting point:
214-215℃
Boiling point:
523.4±50.0 °C(Predicted)
Density 
1.410±0.06 g/cm3(Predicted)
pka
6.59±0.40(Predicted)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone Chemical Properties,Usage,Production

Uses

6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS)[1].

Definition

ChEBI: 6-Deoxyjacareubin is a member of pyranoxanthones.

in vivo

6-Deoxyjacareubin (5 mg/kg, i.p., every seven days for 1 month) attenuates motor neuron loss in familial ALS model mice[1].

Animal Model:Male SOD1G93A mice (eight weeks)[1]
Dosage:5 mg/kg
Administration:Intraperitoneally (i.p.), every seven days for 1 month
Result:Prolonged the survival time of SOD1G93A mice and improved their locomotor dysfunction. Suppressed glial activation and showed protective effect on motor neuron loss.

References

[1] Hoshino T, et al. 6-Deoxyjacareubin, a natural compound preventing hypoxia-induced cell death, ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis. Neurosci Res. 2021 Feb;163:43-51. DOI:10.1016/j.neures.2020.02.011

J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone Preparation Products And Raw materials

Raw materials

Preparation Products

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J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone Suppliers

China 24 United States 4 Global 28
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View Lastest Price from J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
6-Deoxyjacareubin 16265-56-8
Price
US $0.00-0.00/KG
Min. Order
5mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-06

16265-56-8, J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthoneRelated Search:

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