ChemicalBook > CAS DataBase List > 2-Amino-4,5-dichlorophenol
2-Amino-4,5-dichlorophenol
- Product Name
- 2-Amino-4,5-dichlorophenol
- CAS No.
- 28443-57-4
- Chemical Name
- 2-Amino-4,5-dichlorophenol
- Synonyms
- Lenvatinib Impurity 87;2-AMINO-4,5-DICHLORPHENOL;2-Amino-4,5-dichlorophenol;Phenol, 2-amino-4,5-dichloro-;4,5-Dichloro-2-hydroxyaniline
- CBNumber
- CB22205764
- Molecular Formula
- C6H5Cl2NO
- Formula Weight
- 178.02
- MOL File
- 28443-57-4.mol
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2-Amino-4,5-dichlorophenol Property
- Melting point:
- 174-175 °C
- Boiling point:
- 309.1±42.0 °C(Predicted)
- Density
- 1.560±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder
- pka
- 8.36±0.23(Predicted)
- color
- Very dark beige to very dark brown
- EPA Substance Registry System
- Phenol, 2-amino-4,5-dichloro- (28443-57-4)
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Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 29089990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- A596850
- Product name
- 2-Amino-4,5-dichlorophenol
- Packaging
- 500mg
- Price
- $145
- Updated
- 2021/12/16
AK Scientific
- Product number
- V4907
- Product name
- 2-Amino-4,5-dichlorophenol
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4656-5-Y1
- Product name
- 2-Amino-4,5-dichlorophenol
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR16946
- Product name
- 2-Amino-4,5-dichlorophenol
- Packaging
- 250mg
- Price
- $51
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4656-5-Y1
- Product name
- 2-Amino-4,5-dichlorophenol
- Packaging
- 250mg
- Price
- $61
- Updated
- 2021/12/16
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2-Amino-4,5-dichlorophenol Chemical Properties,Usage,Production
Synthesis
39224-65-2
28443-57-4
The general procedure for the synthesis of 2-hydroxy-4,5-dichloroaniline from 4,5-dichloro-2-nitrophenol was as follows: to a stirred mixed solution of 4,5-dichloro-2-nitrophenol (15 g, 72 mmol) in acetic acid (150 mL) and water (450 mL) was added powdered iron (16 g, 285 mmol) in batches. The reaction mixture was stirred continuously at 50 °C for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subjected to filtration operation and the filter cake was washed with ethyl acetate. The filtrate was subsequently extracted with ethyl acetate. The combined organic layers were washed sequentially with water, NaHCO3 (aq.) and brine, dried over Na2SO4 and concentrated under vacuum to give the final target product 2-hydroxy-4,5-dichloroaniline (10 g, 78% yield).
References
[1] Journal of Organic Chemistry, 1996, vol. 61, # 10, p. 3289 - 3297
[2] Patent: US2014/288045, 2014, A1. Location in patent: Paragraph 0456
[3] European Journal of Medicinal Chemistry, 2012, vol. 56, p. 108 - 119
[4] Patent: WO2018/37223, 2018, A1. Location in patent: Page/Page column 81
[5] Journal of the Chemical Society, 1956, p. 4727,4730
2-Amino-4,5-dichlorophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-4,5-dichlorophenol manufacturers
Career Henan Chemical Co
- Product
- 2-Amino-4,5-dichlorophenol 28443-57-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000kgs
- Release date
- 2019-12-18