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THYMINE-1-ACETIC ACID

Product Name
THYMINE-1-ACETIC ACID
CAS No.
20924-05-4
Chemical Name
THYMINE-1-ACETIC ACID
Synonyms
T Acetic acid;Thymine acetic acid;thymidyl acetic acid;THYMINE-1-ACETIC ACID;1-Thyminylacetic acid;Thymin-1-ylacetic acid;1-Carboxymethylthymine;Thymine-N1-acetic acid;Nucleobase-T Acetic acid;ThyMine-1-acetic acid 98%
CBNumber
CB2224925
Molecular Formula
C7H8N2O4
Formula Weight
184.15
MOL File
20924-05-4.mol
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THYMINE-1-ACETIC ACID Property

Melting point:
272-278 °C (dec.) (lit.)
Density 
1.416
storage temp. 
Sealed in dry,Room Temperature
form 
solid
pka
3.81±0.10(Predicted)
color 
White
InChI
InChI=1S/C7H8N2O4/c1-4-2-9(3-5(10)11)7(13)8-6(4)12/h2H,3H2,1H3,(H,10,11)(H,8,12,13)
InChIKey
TZDMCKHDYUDRMB-UHFFFAOYSA-N
SMILES
C1(=O)N(CC(O)=O)C=C(C)C(=O)N1
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
448958
Product name
Thymine-1-acetic acid
Purity
98%
Packaging
5g
Price
$190
Updated
2025/07/31
Sigma-Aldrich
Product number
448958
Product name
Thymine-1-acetic acid
Purity
98%
Packaging
25g
Price
$880.65
Updated
2025/07/31
TCI Chemical
Product number
T4102
Product name
Thymine-1-acetic Acid
Packaging
5G
Price
$183
Updated
2025/07/31
TCI Chemical
Product number
T4102
Product name
Thymine-1-acetic Acid
Packaging
25G
Price
$549
Updated
2025/07/31
TRC
Product number
M305138
Product name
(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)aceticAcid
Packaging
500mg
Price
$75
Updated
2021/12/16
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THYMINE-1-ACETIC ACID Chemical Properties,Usage,Production

Synthesis

79-11-8

65-71-4

20924-05-4

5-Methyluracil (10.0 g, 79.3 mmol) was suspended in distilled water (150 mL). Aqueous potassium hydroxide solution (50 mL, 3.6 M) was slowly added to the suspension. The mixture was stirred at room temperature for 10 minutes until the solution gradually became clear. Subsequently, chloroacetic acid (15.0 g, 159 mmol) was added to the clarified solution. The reaction mixture was heated to reflux and kept for 90 minutes. Upon completion of the reaction, the solution was cooled to room temperature and acidified with concentrated hydrochloric acid to pH=3. The acidified solution was placed in a refrigerator at 4°C overnight to promote the formation of white crystalline precipitate. The white crystalline precipitate was collected by filtration and dried under vacuum using phosphorus pentoxide (P2O5), resulting in 4.5 g of thymine-1-acetic acid in 31% yield.

References

[1] Chemistry - A European Journal, 2000, vol. 6, # 1, p. 62 - 72
[2] Organic and Biomolecular Chemistry, 2006, vol. 4, # 2, p. 291 - 298
[3] Bioconjugate Chemistry, 2016, vol. 27, # 10, p. 2301 - 2306
[4] European Journal of Organic Chemistry, 2013, # 22, p. 4804 - 4815
[5] Patent: CN108478807, 2018, A. Location in patent: Paragraph 0022; 0053; 0070; 0071

THYMINE-1-ACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from THYMINE-1-ACETIC ACID manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
THYMINE-1-ACETIC ACID 20924-05-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-14
Career Henan Chemical Co
Product
THYMINE-1-ACETIC ACID 20924-05-4
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-09

20924-05-4, THYMINE-1-ACETIC ACIDRelated Search:

2-Bromo-5-nitro-1,3,4-thiadiazole SILVER NITRITE CIS-3-HEXENOIC ACID 2-[5-Cyano-6-methyl-2,4-dioxo-3,4-dihydro-(2H)-pyrimidin-1-yl]acetic acid 2-[5-Cyano-2,4-dioxo-3,4-dihydro-(2H)pyrimidin-1-yl]acetic acid [5-(aminocarbonyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]acetic acid (5-METHYL-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-ACETIC ACID METHYL ESTER THYMINE-1-ACETIC ACID

  • THYMINE-1-ACETIC ACID
  • 2-[5-METHYL-2,4-DIOXO-3,4-DIHYDRO-1(2H)-PYRIMIDINYL]ACETIC ACID
  • THYMINE-1-YL-ACETIC ACID
  • [5-Methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]acetic acid
  • Thymin-1-ylacetic acid
  • (5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetic acid
  • ThyMine-1-acetic acid 98%
  • 1-Carboxymethylthymine
  • 1-Thyminylacetic acid
  • 2-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1-yl)acetic acid
  • Thymine acetic acid
  • Thymine-N1-acetic acid
  • 2-(5-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)acetic acid
  • 2-(5-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)acetic acid
  • 2-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)
  • 2-(5-methyl-2,4-dioxopyrimidin-1-yl)acetic acid
  • Thymin-1-ylacetic acid 98%
  • (5-METHYL-2,4-DIOXO-3H-PYRIMIDIN-1-YL)ACETIC ACID
  • Thymine-1-Acetic Acid,>98%
  • 1(2H)-Pyrimidineacetic acid, 3,4-dihydro-5-methyl-2,4-dioxo-
  • 2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin -1-yl)acetic acid
  • Nucleobase-T Acetic acid
  • thymidyl acetic acid
  • T Acetic acid
  • 20924-05-4
  • Heterocyclic Building Blocks
  • Pyrimidines
  • Building Blocks
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyrimidines