3-Bromothieno[2,3-b]pyridine
- Product Name
- 3-Bromothieno[2,3-b]pyridine
- CAS No.
- 28988-21-8
- Chemical Name
- 3-Bromothieno[2,3-b]pyridine
- Synonyms
- NSC 152393;3-Bromothieno[2,3-b]pyridine;Thieno[2,3-b]pyridine, 3-bromo-;3-bromanylthieno[2,3-b]pyridine;3-Bromothieno[2,3-b]pyridine 97%
- CBNumber
- CB22310736
- Molecular Formula
- C7H4BrNS
- Formula Weight
- 214.08
- MOL File
- 28988-21-8.mol
3-Bromothieno[2,3-b]pyridine Property
- Boiling point:
- 299.8±20.0 °C(Predicted)
- Density
- 1.748±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 3.28±0.40(Predicted)
- Appearance
- Off-white to light brown Solid
Safety
- HS Code
- 2934999090
N-Bromosuccinimide Price
- Product number
- B429285
- Product name
- 3-bromothieno[2,3-b]pyridine
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FB141641
- Product name
- 3-Bromothieno[2,3-b]pyridine
- Packaging
- 50mg
- Price
- $56
- Updated
- 2021/12/16
- Product number
- Z4557
- Product name
- 3-Bromothieno[2,3-b]pyridine
- Packaging
- 100mg
- Price
- $91
- Updated
- 2021/12/16
- Product number
- FB141641
- Product name
- 3-Bromothieno[2,3-b]pyridine
- Packaging
- 100mg
- Price
- $98
- Updated
- 2021/12/16
- Product number
- Z4557
- Product name
- 3-Bromothieno[2,3-b]pyridine
- Packaging
- 250mg
- Price
- $111
- Updated
- 2021/12/16
3-Bromothieno[2,3-b]pyridine Chemical Properties,Usage,Production
Synthesis
272-23-1
28988-21-8
The general procedure for the synthesis of 3-bromothieno[2,3-b]pyridine from thieno[2,3-b]pyridine was as follows: 2.30 g of thieno[2,3-b]pyridine (17 mmol), 1.43 g of NaHCO3 (17 mmol), 4.44 g of K2HPO4 (25.5 mmol) and 2.66 g of MgSO4 (22.1 mmol) were were placed in a reaction flask and 80 mL of dichloromethane was added. The reaction mixture was heated to reflux with continuous stirring. 1.05 mL of bromine (20.4 mmol) was slowly added dropwise to the reaction system and stirring was continued overnight. Upon completion of the reaction, the cooled reaction mixture was extracted with dichloromethane and water to separate the organic phase. The organic phase was dried with anhydrous Na2SO4 and subsequently concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 3:1) to afford 1.76 g of 3-bromothieno[2,3-b]pyridine in 48% yield. The product was characterized and confirmed by mass spectrometry (m/e): 215 (M+1) and 1H-NMR (CDCl3): δ 8.67 (m, 1H), 8.13 (m, 1H), 7.59 (s, 1H), 7.45 (m, 1H) ppm.
References
[1] Patent: WO2006/107784, 2006, A1. Location in patent: Page/Page column 94
[2] Journal of Heterocyclic Chemistry, 1974, vol. 11, p. 205 - 209
[3] Patent: WO2011/79804, 2011, A1. Location in patent: Page/Page column 33
[4] Patent: US2012/245178, 2012, A1. Location in patent: Page/Page column 19
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 18, p. 7577 - 7589
3-Bromothieno[2,3-b]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Bromothieno[2,3-b]pyridine manufacturers
- Product
- 3-Bromothieno[2,3-b]pyridine 28988-21-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- MIn98%HPLC/LC
- Supply Ability
- 100KGS
- Release date
- 2020-10-29