CALPAIN INHIBITOR XII

Product Name: CALPAIN INHIBITOR XII
CAS No.: 181769-57-3
Chemical Name: CALPAIN INHIBITOR XII
Synonyms: Z-L-NVA-CONH-CH2-2-PY;CALPAIN INHIBITOR XII;(Rac)-Calpain Inhibitor XII;PLVWMBFPIAQRHK-UHFFFAOYSA-N;benzyl N-[1-[[1,2-dioxo-1-(pyridin-2-ylmethylamino)hexan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate;Carbamic acid, [3-methyl-1-[[[1-[oxo[(2-pyridinylmethyl)amino]acetyl]butyl]amino]carbonyl]butyl]-, phenylmethyl ester (9CI)
CBNumber: CB2243292
Molecular Formula: C26H34N4O5
Formula Weight: 482.57
MOL File: Mol file

More

Less

CALPAIN INHIBITOR XII Property

Density: 1.167±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤16mg/ml in ethanol;16mg/ml in DMSO;20mg/ml in dimethyl formamide
form: crystalline solid
pka: 10.58±0.46(Predicted)
color: White to yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Alfa Aesar

Product number: J64751
Product name: Calpain Inhibitor XII
Packaging: 1mg
Price: $111
Updated: 2023/06/20

Alfa Aesar

Product number: J64751
Product name: Calpain Inhibitor XII
Packaging: 5mg
Price: $463
Updated: 2023/06/20

Cayman Chemical

Product number: 14466
Product name: Calpain Inhibitor XII
Purity: ≥90%
Packaging: 1mg
Price: $101
Updated: 2024/03/01

Cayman Chemical

Product number: 14466
Product name: Calpain Inhibitor XII
Purity: ≥90%
Packaging: 5mg
Price: $449
Updated: 2024/03/01

Cayman Chemical

Product number: 14466
Product name: Calpain Inhibitor XII
Purity: ≥90%
Packaging: 10mg
Price: $747
Updated: 2024/03/01

More

Less

CALPAIN INHIBITOR XII Chemical Properties,Usage,Production

Description

Calpain inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, K_i = 19 nM), with lower affinities for calpain II (m-calpain, K_i = 120 nM) and cathepsin B (K_i = 750 nM). Calpain inhibitors, including this compound, have been used to study the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury.

Uses

A cell-permeable dipeptidyl -ketoamide compound that acts as a potent, selective, reversible, and active site inhibitor of calpain-1

in vitro

a series of new dipeptidyl alpha-keto amides of the general structure r1-l-leu-d,l-aa-conh-r2 including calpain inhibitor xii were synthesized and evaluated as inhibitors for the cysteine proteases calpain i, calpain ii, and cathepsin b. calpain ii was more sensitive to these inhibitors calpain inhibitor xii than calpain i. calpain i was also effectively inhibited by calpain inhibitor xii, but lower ki values than with calpain ii. cathepsin b was weakly inhibited by calpain inhibitor xii. the best calpain i inhibitor in this study was calpain inhibitor xii with ki value of 19 nm [1].

References

[1] li, z. ,ortega-vilain, a.c.,patil, g.s., et al. novel peptidyl α-keto amide inhibitors of calpains and other cysteine proteases. journal of medicinal chemistry 39(20), 4089-4098 (1996).

CALPAIN INHIBITOR XII Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

CALPAIN INHIBITOR XII Suppliers

China 31 United States 8 Global 39

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Fax: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 6756
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3251
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11217
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 7973
Advantage: 58

Changzhou Furuisi Biotechnology Co., Ltd

Tel: 0519-85524369
Email: 3477467573@qq.com
Country: China
ProdList: 8617
Advantage: 58

Nantong Hi-Future Biotechnology Co., Ltd

Tel: 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 3056
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

Wuhan Augda Biotechnology Co., Ltd

Tel: 15071299552
Fax: QQ:262933239
Email: 262933239@qq.com
Country: China
ProdList: 6883
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24647
Advantage: 58

Xianning Shen Lan Biomedical Research and Development Co., Ltd.

Tel: 18171815831
Email: 1341138380@qq.com
Country: China
ProdList: 3271
Advantage: 58

Shanghai Yiyan Biotechnology Co. , Ltd.

Tel: 021-69985186 13611928337
Email: 3427709316@qq.com
Country: China
ProdList: 7979
Advantage: 58

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: 18616537568
Email: hanfangpharma@126.com
Country: China
ProdList: 30961
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9272
Advantage: 58

Olix (Shanghai) Pharmaceutical Technology Co., Ltd

Tel: 17316404525
Email: 209533805@qq.com
Country: China
ProdList: 9762
Advantage: 58

Wuhan Topule Biopharmaceutical Co., Ltd

Tel: +8618327326525
Email: masar@topule.com
Country: China
ProdList: 8467
Advantage: 58

Nantong HI-FUTURE Biology Co., Ltd.

Tel: +undefined18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 3135
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6654
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Shanghai Haoran Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 470003480@QQ.COM
Country: CHINA
ProdList: 6955
Advantage: 58

Shanghai Jijin Chemical Technology Co., Ltd.

Tel: --
Fax: --
Email: jijinhuaxue@sina.com
Country: CHINA
ProdList: 6606
Advantage: 58

Shanghai Benrui Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: john.st@163.com
Country: CHINA
ProdList: 1471
Advantage: 58

Shanghai Minmin Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1914109725@qq.com
Country: CHINA
ProdList: 6518
Advantage: 58

Shanghai Yaoyun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 912529879@qq.com
Country: CHINA
ProdList: 6835
Advantage: 58

Shanghai Ziqi Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 2453006496@qq.com
Country: CHINA
ProdList: 6184
Advantage: 58

Shanghai Weiwei Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: sales@wheybio.com
Country: CHINA
ProdList: 4398
Advantage: 58

Boao Pike

Tel: --
Fax: --
Email: lyn@biopike.com.cn
Country: CHINA
ProdList: 6629
Advantage: 58

Beijing Zhijie Fangyuan Technology Co., Ltd.

Tel: --
Fax: --
Email: 15810200961@163.com
Country: CHINA
ProdList: 6984
Advantage: 58

Merck Life Sciences

Tel: --
Fax: --
Email: yanlei@gongye360.com
Country: CHINA
ProdList: 783
Advantage: 58

Beijing Taize Ruida Technology Co., Ltd.

Tel: --
Fax: --
Email: taizeorder@163.com
Country: CHINA
ProdList: 6536
Advantage: 58

Morning Student Science and Technology (Guangzhou) Co., Ltd.

Tel: --
Fax: --
Email: chenxue_gz@163.com
Country: CHINA
ProdList: 6600
Advantage: 58

More

Less

View Lastest Price from CALPAIN INHIBITOR XII manufacturers

Career Henan Chemica Co

Product: CALPAIN INHIBITOR XII 181769-57-3
Price: US $17.00/g
Min. Order: 25g
Purity: 95%
Supply Ability: 1KG
Release date: 2020-10-27

181769-57-3, CALPAIN INHIBITOR XIIRelated Search:

Z-L-NVA-CONH-CH2-2-PY

benzyl N-[1-[[1,2-dioxo-1-(pyridin-2-ylmethylamino)hexan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate

PLVWMBFPIAQRHK-UHFFFAOYSA-N

CALPAIN INHIBITOR XII

Carbamic acid, [3-methyl-1-[[[1-[oxo[(2-pyridinylmethyl)amino]acetyl]butyl]amino]carbonyl]butyl]-, phenylmethyl ester (9CI)

(Rac)-Calpain Inhibitor XII

181769-57-3

C26H34N4O5