RG-13022
- Product Name
- RG-13022
- CAS No.
- 149286-90-8
- Chemical Name
- RG-13022
- Synonyms
- (Z)-RG-13022;3-Pyridineacetonitrile, α-[(3,4-dimethoxyphenyl)methylene]-, (αZ)-
- CBNumber
- CB22446493
- Molecular Formula
- C16H14N2O2
- Formula Weight
- 266.29456
- MOL File
- 149286-90-8.mol
RG-13022 Property
- Boiling point:
- 423.8±45.0 °C(Predicted)
- Density
- 1.172±0.06 g/cm3(Predicted)
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 2 mg/ml
- form
- A crystalline solid
- pka
- 3.74±0.12(Predicted)
N-Bromosuccinimide Price
- Product number
- 10010309
- Product name
- RG-13022
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $59
- Updated
- 2024/03/01
- Product number
- 10010309
- Product name
- RG-13022
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $108
- Updated
- 2024/03/01
- Product number
- 10010309
- Product name
- RG-13022
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $448
- Updated
- 2024/03/01
- Product number
- KIN0000789
- Product name
- RG-13022
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $628.9
- Updated
- 2021/12/16
- Product number
- KIN0000789
- Product name
- RG-13022
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $982.33
- Updated
- 2021/12/16
RG-13022 Chemical Properties,Usage,Production
Description
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds that act as PTK blockers. PTK inhibitors that preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-
Uses
(Z)-RG-13022 is a tyrosine kinase (TK) inhibitor, which inhibits preferentially the TK activity of the EGF receptor and inhibits EGF-stimulated growth of cultured cells. (Z)-RG-13022 exerts an IC50 of 11 μM for DNA synthesis in the HN5 cells, which is 3 times more potent than (E)-RG-13022 (IC50=38 μM). (Z)-RG-13022 can be used for research of breast cancer cells[1][2].
Definition
ChEBI: 3-(3,4-dimethoxyphenyl)-2-(3-pyridinyl)-2-propenenitrile is a dimethoxybenzene.
References
[1] Reddy KB, et al. Inhibition of breast cancer cell growth in vitro by a tyrosine kinase inhibitor. Cancer Res. 1992 Jul 1;52(13):3636-41. PMID:1617636
[2] McLeod HL, et al. In vivo pharmacology and anti-tumour evaluation of the tyrphostin tyrosine kinase inhibitor RG13022. Br J Cancer. 1996 Dec;74(11):1714-8. DOI:10.1038/bjc.1996.620
RG-13022 Preparation Products And Raw materials
Raw materials
Preparation Products
RG-13022 Suppliers
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