GW 9578
- Product Name
- GW 9578
- CAS No.
- 247923-29-1
- Chemical Name
- GW 9578
- Synonyms
- GW 9578;GW 9578 Exclusive;KYQNYMXQHLMADB-UHFFFAOYSA-N;Propanoic acid, 2-[[4-[2-[[[(2,4-difluorophenyl)amino]carbonyl]heptylamino]ethyl]phenyl]thio]-2-methyl-
- CBNumber
- CB22448578
- Molecular Formula
- C26H34F2N2O3S
- Formula Weight
- 492.6215664
- MOL File
- 247923-29-1.mol
GW 9578 Property
- Boiling point:
- 641.7±55.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF:10.0(Max Conc. mg/mL);20.3(Max Conc. mM)
DMSO:10.0(Max Conc. mg/mL);20.3(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.61(Max Conc. mM)
Ethanol:2.5(Max Conc. mg/mL);5.07(Max Conc. mM) - pka
- 3.77±0.10(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
H336May cause drowsiness or dizziness
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 10011211
- Product name
- GW 9578
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $30
- Updated
- 2024/03/01
- Product number
- 10011211
- Product name
- GW 9578
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $56
- Updated
- 2024/03/01
- Product number
- 10011211
- Product name
- GW 9578
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $225
- Updated
- 2024/03/01
- Product number
- 10011211
- Product name
- GW 9578
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $392
- Updated
- 2024/03/01
- Product number
- 3831CR
- Product name
- CID9870304
- Packaging
- 10mg
- Price
- $534
- Updated
- 2021/12/16
GW 9578 Chemical Properties,Usage,Production
Uses
GW9578 is a subtype-selective PPARα agonist (EC50s of 5 and 50 nM for murine and human PPAR-α) with potent lipid-lowering activity[1][2].
IC 50
mouse PPARα: 5 nM (EC50); h-PPARα: 50 nM (EC50)
References
[1] P J Brown, et al. A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. J Med Chem. 1999 Sep 23;42(19):3785-8. DOI:10.1021/jm9903601
[2] Alexandre Trifilieff, et al. PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-kappaB-independent effect. Br J Pharmacol. 2003 May;139(1):163-71. DOI:10.1038/sj.bjp.0705232
[3] Dallas C Jones, et al. Nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) is expressed in resting murine lymphocytes. The PPARalpha in T and B lymphocytes is both transactivation and transrepression competent. J Biol Chem. 2002 DOI:10.1074/jbc.M106908200
GW 9578 Preparation Products And Raw materials
Raw materials
Preparation Products
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