ACOLBIFENE

Product Name: ACOLBIFENE
CAS No.: 151533-34-5
Chemical Name: ACOLBIFENE
Synonyms: ACOLBIFENE;(Rac)-EM-652;rac-Acolbifene;2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-;2-[4-[2-(1-piperidino)ethoxy]phenyl]-3-(4-hydroxyphenyl)-4-Methyl-7-hydroxy-2H-1-benzopyran
CBNumber: CB22451259
Molecular Formula: C29H31NO4
Formula Weight: 457.56
MOL File: 151533-34-5.mol

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ACOLBIFENE Property

Boiling point:: 651.5±55.0 °C(Predicted)
Density: 1.217±0.06 g/cm3(Predicted)
solubility: DMSO: 100 mg/mL (218.55 mM)
pka: 9.70±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A190235
Product name: rac-Acolbifene
Packaging: 10mg
Price: $165
Updated: 2021/12/16

TRC

Product number: A190235
Product name: rac-Acolbifene
Packaging: 100mg
Price: $1320
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0019241
Product name: ACOLBIFENE
Purity: 95.00%
Packaging: 5MG
Price: $501.22
Updated: 2021/12/16

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ACOLBIFENE Chemical Properties,Usage,Production

Description

The prodrug EM-800 is an orally active nonsteroidal anties trogen and is a triphenylethylene rigid analogue. EM-800 undergoes ester hydrolysis to the active m etabolite acolbifene. This fourth-generation antiestrogen is 200-fold more potent than tam oxifen in breast and uterine cancer cells and is effective in patients for whom tamoxifen therapy has failed. The mechanistic rationale for the effectiveness of acolbifene in tamoxifen-resistant tumors is based on the fact that it inhibits both the AF-1 and AF-2 activation pathways and does not poss ess any intrinsic estrogenic action. Acolbifene enjoys a 60% breast cancer cure rate. Structurally, acolbifene resembles raloxifene, with a benzopyran ring substituted for the benz othiophene ring. An additional benefit observed with acolbifene is its protective effect on bone loss. Adverse effects include nausea and vomiting.

Uses

rac-Acolbifene is a reacemic compound of Acolbifene (A190230) which is a selective estrogen receptor modulator (SERM) acting as pure antiestrogen. Acolbifene is also the orally active antiestrogen which is the most potent of the known antiestrogens and exerts pure antiestrogenic activity in the mammary gland and endometrium.

ACOLBIFENE Preparation Products And Raw materials

Raw materials

Preparation Products

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ACOLBIFENE Suppliers

China 18 India 1 United States 3 Global 22

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
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NCE Biomedical Co.,Ltd.

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LETOPHARM LIMITED

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Email: sales@letopharm.com
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SPIRO PHARMA

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Shenzhen Polymeri Biochemical Technology Co., Ltd.

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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
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Energy Chemical

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Beijing Jin Ming Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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151533-34-5, ACOLBIFENERelated Search:

ACOLBIFENE CDRI 85-287

2-[4-[2-(1-piperidino)ethoxy]phenyl]-3-(4-hydroxyphenyl)-4-Methyl-7-hydroxy-2H-1-benzopyran

rac-Acolbifene

ACOLBIFENE

(Rac)-EM-652

2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-

151533-34-5