ChemicalBook > CAS DataBase List > 7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE
7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE
Uses- Product Name
- 7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE
- CAS No.
- 31169-25-2
- Chemical Name
- 7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE
- Synonyms
- KML-121;7-bromothieno[3,2-d]pyrimidin-4-ol;7-BroMo-3H-thieno[3,2-d]pyriMidin-4-one;7-bromothieno[3,2-d]pyrimidin-4(3H)-one;7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE;Thieno[3,2-d]pyrimidin-4(3H)-one, 7-bromo-;7-bromo-3H,4H-thieno[3,2-d]pyrimidin-4-one;7-broMo-1H,4H-thieno[3,2-d]pyriMidin-4-one;7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE ISO 9001：2015 REACH
- CBNumber
- CB22452786
- Molecular Formula
- C6H3BrN2OS
- Formula Weight
- 231.07
- MOL File
- 31169-25-2.mol
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7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE Property
- Boiling point:
- 452.7±30.0 °C(Predicted)
- Density
- 2.18
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 10.19±0.20(Predicted)
- Appearance
- Off-white to light brown Solid
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- PHB00093
- Product name
- 7-Bromothieno[3,2-d]pyrimidin-4(1H)-one
- Purity
- AldrichCPR
- Packaging
- 1G
- Price
- $259
- Updated
- 2025/07/31
TRC
- Product number
- B688438
- Product name
- 7-Bromothieno[3,2-d]pyrimidin-4(1h)-one
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 8H48-9-01
- Product name
- 7-Bromo-1H-thieno[3,2-d]pyrimidin-4-one
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB144202
- Product name
- 7-Bromothieno[3,2-d]pyrimidin-4(1H)-one
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
AK Scientific
- Product number
- W5326
- Product name
- 7-Bromothieno[3,2-d]pyrimidin-4(1H)-one
- Packaging
- 250mg
- Price
- $109
- Updated
- 2021/12/16
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7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE Chemical Properties,Usage,Production
Uses
7-Bromothieno[3,2-D]pyrimidine-4(1H)-one is a useful research chemical for organic synthesis and other chemical processes.
Synthesis
16234-10-9
31169-25-2
The general procedure for the synthesis of 7-bromothieno[3,2-d]pyrimidin-4(1H)-one from thieno[3,2-d]pyrimidin-4(3H)-one (38.0 g, 0.25 mol) was as follows: a dilution of bromine (40.4 mL, 0.78 mol) in acetic acid (122 mL, 2.1 mol) was slowly added to a thieno[3,2-d]pyrimidin -4(3H)-one solution in acetic acid (143 mL, 2.5 mol). The reactor was sealed and the reaction mixture was stirred at 120°C for 18 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the acetic acid was subsequently removed by distillation under reduced pressure. The concentrate was poured into ice water and precipitate was precipitated, which was filtered and dried to afford the target compound 7-bromothieno[3,2-d]pyrimidin-4(1H)-one (37.5 g, 65% yield) without further purification. The product was characterized by 1H-NMR (300 MHz, DMSO-d6): δ 12.75 (brs, 1H), 8.36 (s, 1H), 8.24 (s, 1H).
References
[1] Patent: WO2014/3483, 2014, A1. Location in patent: Page/Page column 19
[2] Patent: US2014/371219, 2014, A1. Location in patent: Paragraph 0204; 0205
[3] Patent: US2006/4002, 2006, A1. Location in patent: Page/Page column 38
[4] Patent: WO2011/25940, 2011, A1. Location in patent: Page/Page column 83
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 6, p. 2869 - 2881
7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- 7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE 31169-25-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22
Dideu Industries Group Limited
- Product
- 7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE 31169-25-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-01
31169-25-2, 7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONERelated Search:
7-bromothieno[3,2-d]pyrimidine
7-Bromothieno[2,3-b]pyrazine
4-BROMO-2-THIOPHENECARBOXAMIDE
7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE
THIENO[3,2-D]PYRIMIDIN-4(3H)-ONE
Methyl 7-bromothieno[2,3-c]pyridine-2-carboxylate