ETHYL 2-(BROMOMETHYL)-1,3-THIAZOLE-4-CARBOXYLATE
Uses- Product Name
- ETHYL 2-(BROMOMETHYL)-1,3-THIAZOLE-4-CARBOXYLATE
- CAS No.
- 78502-71-3
- Chemical Name
- ETHYL 2-(BROMOMETHYL)-1,3-THIAZOLE-4-CARBOXYLATE
- Synonyms
- ETHYL 2-(BROMOMETHYL)THIAZOLE-4-CARBOXYLATE;ETHYL 2-(BROMOMETHYL)-1,3-THIAZOLE-4-CARBOXYLATE;4-Thiazolecarboxylic acid, 2-(bromomethyl)-, ethyl ester
- CBNumber
- CB22453248
- Molecular Formula
- C7H8BrNO2S
- Formula Weight
- 250.11
- MOL File
- 78502-71-3.mol
ETHYL 2-(BROMOMETHYL)-1,3-THIAZOLE-4-CARBOXYLATE Property
- Boiling point:
- 290.8±20.0 °C(Predicted)
- Density
- 1.602±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- -0.45±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- HCH0360186
- Product name
- ETHYL-2-(BROMOMETHYL)-1,3-THIAZOLE-4-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496
- Updated
- 2021/12/16
- Product number
- 3570CS
- Product name
- Ethyl2-(bromomethyl)-1,3-thiazole-4-carboxylate
- Packaging
- 500mg
- Price
- $791
- Updated
- 2021/12/16
- Product number
- CD11057164
- Product name
- Ethyl2-(bromomethyl)thiazole-4-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $505
- Updated
- 2021/12/16
- Product number
- 78502713
- Product name
- Ethyl2-(bromomethyl)thiazole-4-carboxylate
- Packaging
- 1g
- Price
- $510
- Updated
- 2021/12/16
- Product number
- A692111
- Product name
- Ethyl2-(bromomethyl)thiazole-4-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $548
- Updated
- 2021/12/16
ETHYL 2-(BROMOMETHYL)-1,3-THIAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production
Uses
2-Bromomethyl-4-carboxylic acid ethyl thiazole is a monobrominated methylthiazole derivative with good reactivity and is often used as a substructure for pre-molecular modification of drugs.
Synthesis
6436-59-5
78502-71-3
General procedure for the synthesis of ethyl 2-(bromomethyl)thiazole-4-carboxylate from ethyl 2-methylthiazole-4-carboxylate: ethyl 2-methyl-1,3-thiazole-4-carboxylate (500 mg, 2.92 mmol) was dissolved in carbon tetrachloride (10 mL), N-bromosuccinimide (NBS, 624 mg, 3.50 mmol) was added, and the reaction mixture was heated at 76 °C for 60 min. Subsequently, azobisisobutyronitrile (AIBN, 36 mg, 0.21 mmol) was added and heating was continued at 76 °C for 4 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered through diatomaceous earth. The filter cake was washed with dichloromethane (DCM). The organic layers were combined, concentrated in vacuum through a silica column and purified using fast column chromatography (FCC) with a heptane solution of 50% ethyl acetate (EtOAc) as eluent to give the final ethyl 2-(bromomethyl)thiazole-4-carboxylate. Yield: 274 mg in 38% yield.
References
[1] Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 1, p. 1 - 6
[2] Patent: WO2010/20556, 2010, A1. Location in patent: Page/Page column 156
[3] Patent: US2006/122256, 2006, A1. Location in patent: Page/Page column 21
[4] Patent: US2004/266856, 2004, A1. Location in patent: Page/Page column 19
[5] Liebigs Annalen der Chemie, 1981, # 4, p. 623 - 632
ETHYL 2-(BROMOMETHYL)-1,3-THIAZOLE-4-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ETHYL 2-(BROMOMETHYL)-1,3-THIAZOLE-4-CARBOXYLATE manufacturers
- Product
- Ethyl 2-(bromomethyl)thiazole-4-carboxylate 78502-71-3
- Price
- US $0.00/KG
- Min. Order
- 0.0001KG
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-11