METHYL 2-CHLORO-5-HYDROXYBENZOATE

Product Name: METHYL 2-CHLORO-5-HYDROXYBENZOATE
CAS No.: 247092-10-0
Chemical Name: METHYL 2-CHLORO-5-HYDROXYBENZOATE
Synonyms: METHYL 2-CHLORO-5-HYDROXYBENZOATE;2-Chloro-5-hydroxybenzoic acid Methyl ester;Benzoic acid, 2-chloro-5-hydroxy-, methyl ester
CBNumber: CB22454700
Molecular Formula: C8H7ClO3
Formula Weight: 186.59
MOL File: 247092-10-0.mol

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METHYL 2-CHLORO-5-HYDROXYBENZOATE Property

Boiling point:: 320.1±22.0 °C(Predicted)
Density: 1.354±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 8.70±0.18(Predicted)
form: solid
color: Grey-yellow

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Safety

HS Code: 2918290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M295738
Product name: Methyl2-chloro-5-hydroxybenzoate
Packaging: 250mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: X5097
Product name: Methyl2-chloro-5-hydroxybenzoate
Packaging: 1g
Price: $217
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0369184
Product name: METHYL-2-CHLORO-5-HYDROXYBENZOATE
Purity: 95.00%
Packaging: 5MG
Price: $499.37
Updated: 2021/12/16

Ambeed

Product number: A111023
Product name: Methyl2-chloro-5-hydroxybenzoate
Purity: 97%
Packaging: 100mg
Price: $38
Updated: 2021/12/16

Ambeed

Product number: A111023
Product name: Methyl2-chloro-5-hydroxybenzoate
Purity: 97%
Packaging: 250mg
Price: $56
Updated: 2021/12/16

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METHYL 2-CHLORO-5-HYDROXYBENZOATE Chemical Properties,Usage,Production

Synthesis

67-56-1

56961-30-9

247092-10-0

To a solution of 2-chloro-5-hydroxybenzoic acid (4 g, 23.6 mmol) in methanol (50 mL) cooled to 0 °C was added thionyl chloride (2.5 mL, 35 mmol) dropwise. The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was dissolved in ethyl acetate (100 mL). The organic phase was washed sequentially with saturated sodium bicarbonate solution (3 x 50 mL), water (50 mL) and brine (50 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The product was white crystals in 99% yield, melting point 96-97 °C. 1H NMR (400 MHz, CDCl3) δ: 3.91 (s, 3H, OCH3), 6.91 (dd, J=8.7, 3.1 Hz, 1H, Ar-H), 7.27 (d, J=8.7 Hz, 1H, Ar-H), 7.31 (d, J=3.1 Hz, 1H Ar-H).13C NMR (100MHz, CDCl3) δ: 52.79, 118.15, 120.33, 124.67, 130.25, 132.14, 154.51, 166.77.ESI HRMS Calculated value [M+H]+: 187.0162, Measured value: 187.0155.HPLC retention Time tR = 10.618 min (100% detection at both 220 nm and 254 nm).

References

[1] European Journal of Medicinal Chemistry, 2014, vol. 73, p. 83 - 96
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 13, p. 3141 - 3147
[3] Gazzetta Chimica Italiana, 1899, vol. 29 I, p. 376
[4] Patent: WO2012/114268, 2012, A1. Location in patent: Page/Page column 119-120
[5] Patent: US2014/73651, 2014, A1. Location in patent: Paragraph 0879; 0880

METHYL 2-CHLORO-5-HYDROXYBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 2-CHLORO-5-HYDROXYBENZOATE Suppliers

China 48 India 2 Switzerland 1 United Kingdom 1 United States 6 Global 58

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247092-10-0, METHYL 2-CHLORO-5-HYDROXYBENZOATERelated Search:

2-CHLORO-3,5-DIHYDROXYBENZOIC ACID ETHYL ESTER ethyl 6-chloro-2-fluoro-3-methoxybenzoate AURORA 1315 RARECHEM AL BF 1492 BENZOIC ACID, 2-CHLORO-5-HYDROXY-, ETHYL ESTER RARECHEM AL BI 0917 RARECHEM AL BF 0917 ETHOXYFEN methyl 6-chloro-2-fluoro-3-methoxybenzoate 2-CHLORO-3,5-DIHYDROXYBENZOIC ACID METHYL ESTER RARECHEM AL BI 1492 METHYL 2-CHLORO-5-HYDROXYBENZOATE

METHYL 2-CHLORO-5-HYDROXYBENZOATE

2-Chloro-5-hydroxybenzoic acid Methyl ester

Benzoic acid, 2-chloro-5-hydroxy-, methyl ester

247092-10-0