4-AMINO-5-IODO-2-METHYLPYRIDINE

Product Name: 4-AMINO-5-IODO-2-METHYLPYRIDINE
CAS No.: 849353-19-1
Chemical Name: 4-AMINO-5-IODO-2-METHYLPYRIDINE
Synonyms: 5-Iodo-2-methyl-4-pyridinamine;5-iodo-2-Methylpyridin-4-aMine;4-AMINO-5-IODO-2-METHYLPYRIDINE;2-Methyl-4-amino-5-iodopyridine;5-Iodo-2-methylpyridin-4-ylamine;4-PyridinaMine, 5-iodo-2-Methyl-
CBNumber: CB22455277
Molecular Formula: C6H7IN2
Formula Weight: 234.04
MOL File: 849353-19-1.mol

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4-AMINO-5-IODO-2-METHYLPYRIDINE Property

storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
Appearance: White to off-white Solid
InChI: InChI=1S/C6H7IN2/c1-4-2-6(8)5(7)3-9-4/h2-3H,1H3,(H2,8,9)
InChIKey: UJDOLPPZRSZZAS-UHFFFAOYSA-N
SMILES: C1(C)=NC=C(I)C(N)=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: X5596
Product name: 5-Iodo-2-methyl-4-pyridinamine
Packaging: 100mg
Price: $158
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0361217
Product name: 4-AMINO-5-IODO-2-METHYLPYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $500.12
Updated: 2021/12/16

Ambeed

Product number: A173674
Product name: 5-Iodo-2-methylpyridin-4-amine
Purity: 95+%
Packaging: 250mg
Price: $86
Updated: 2021/12/16

Ambeed

Product number: A173674
Product name: 5-Iodo-2-methylpyridin-4-amine
Purity: 95+%
Packaging: 1g
Price: $134
Updated: 2021/12/16

Chemenu

Product number: CM132492
Product name: 5-iodo-2-methylpyridin-4-amine
Purity: 95%
Packaging: 1g
Price: $297
Updated: 2021/12/16

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4-AMINO-5-IODO-2-METHYLPYRIDINE Chemical Properties,Usage,Production

Synthesis

18437-58-6

849353-19-1

General procedure for the synthesis of 5-iodo-2-methylpyridin-4-amine (i55) from 2-methylpyridin-4-amine: to a solution of 2-methylpyridin-4-amine (5 g, 46 mmol) in water (25 mL) was added sodium carbonate (Na2CO3, 3.4 g, 32 mmol) and the reaction mixture was heated to reflux. Subsequently, potassium iodide (KI, 9.8 g, 59 mmol) and iodine (I2, 9.3 g, 36 mmol, dissolved in 50 mL of water) were added and the reaction was continued at reflux for 7 hours. Upon completion of the reaction, the reaction was quenched with sodium thiosulfate solution followed by extraction of the target compound with dichloromethane (DCM). The organic layer was separated, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The resulting residue was purified by column chromatography on silica gel (100-200 mesh) using a hexane solution of 25% ethyl acetate as eluent to give the final target product 5-iodo-2-methylpyridin-4-amine (i55) (0.85 g, 8% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 2.20 (s, 3H), 6.00 (s, 2H), 6.49 (s, 1H), 8.22 (s, 1H). Mass spectrum (ESI) showed m/e(M + 1)+: 235.

References

[1] Patent: WO2016/124508, 2016, A1. Location in patent: Page/Page column 68; 69

4-AMINO-5-IODO-2-METHYLPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMINO-5-IODO-2-METHYLPYRIDINE Suppliers

China 23 Germany 1 India 1 United States 4 Global 29

Jiangsu Yaoheng Pharmaceutical Technology Co., Ltd.

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Shanghai Jizhi Biochemical Technology Co. Ltd.

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849353-19-1, 4-AMINO-5-IODO-2-METHYLPYRIDINERelated Search:

3-IODO-4-AMINO-2,6-DIMETHYLPYRIDINE 2-METHYL-5-IODOPYRIDINE 4-AMINO-5-IODO-2-METHYLPYRIDINE 3-Iodo-4-aminopyridine 4-Amino-5-iodo-2-phenylpyridine

4-AMINO-5-IODO-2-METHYLPYRIDINE

5-iodo-2-Methylpyridin-4-aMine

4-PyridinaMine, 5-iodo-2-Methyl-

5-Iodo-2-methyl-4-pyridinamine

5-Iodo-2-methylpyridin-4-ylamine

2-Methyl-4-amino-5-iodopyridine

849353-19-1