4-AMINO-2-CHLOROTHIENO[3,2-D]PYRIMIDINE
- Product Name
- 4-AMINO-2-CHLOROTHIENO[3,2-D]PYRIMIDINE
- CAS No.
- 16234-40-5
- Chemical Name
- 4-AMINO-2-CHLOROTHIENO[3,2-D]PYRIMIDINE
- Synonyms
- 2-chlorothieno[3,2-d]pyriMidin-4-aMine;4-AMINO-2-CHLOROTHIENO[3,2-D]PYRIMIDINE;Thieno[3,2-d]pyrimidin-4-amine, 2-chloro-;4-AMINO-2-CHLOROTHIENO[3,2-D]PYRIMIDINE ISO 9001：2015 REACH
- CBNumber
- CB22455954
- Molecular Formula
- C6H4ClN3S
- Formula Weight
- 185.63
- MOL File
- 16234-40-5.mol
4-AMINO-2-CHLOROTHIENO[3,2-D]PYRIMIDINE Property
- Boiling point:
- 326.0±24.0 °C(Predicted)
- Density
- 1.632±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 4.13±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A596050
- Product name
- 4-Amino-2-chlorothieno[3,2-d]pyrimidine
- Packaging
- 25mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- A596050
- Product name
- 4-Amino-2-chlorothieno[3,2-d]pyrimidine
- Packaging
- 50mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- FA154343
- Product name
- 4-Amino-2-chlorothieno[3,2-d]pyrimidine
- Packaging
- 250mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- FA154343
- Product name
- 4-Amino-2-chlorothieno[3,2-d]pyrimidine
- Packaging
- 500mg
- Price
- $295
- Updated
- 2021/12/16
- Product number
- W3539
- Product name
- 4-Amino-2-chlorothieno[3,2-d]pyrimidine
- Packaging
- 1g
- Price
- $357
- Updated
- 2021/12/16
4-AMINO-2-CHLOROTHIENO[3,2-D]PYRIMIDINE Chemical Properties,Usage,Production
Synthesis
16234-14-3
16234-40-5
General procedure for the synthesis of 4-amino-2-chlorothieno[3,2-d]pyrimidines from 2,4-dichlorothieno[3,2-d]pyrimidines: in a glass tube, 2,4-dichlorothieno[3,2-d]pyrimidines (800 mg, 3.90 mmol) were suspended in methanol (10 mL) and the suspension was cooled to -60 to -70 °C. Ammonia was passed into the cooled suspension. After sealing the glass tube, the reaction mixture was stirred at room temperature overnight until a clarified solution was formed. Subsequently, the solvent was removed by evaporation, and the resulting crude product was purified by column chromatography, sequentially using 9:1 hexane/ethyl acetate and 8:2 hexane/ethyl acetate as eluent, to afford 4-amino-2-chlorothieno[3,2-d]pyrimidine as an off-white solid (575 mg, 3.10 mmol, 80% yield). Thin layer chromatography (TLC) analysis showed an Rf value of 0.2 (unfolding agent was 3:1 hexane/ethyl acetate). The melting point of the compound was 272.3-274.2 °C. Nuclear magnetic resonance hydrogen spectrum (1H NMR, 400 MHz, DMSO-d6): δ 7.73 (d, 1H, J = 5.0 Hz), 8.38 (br s, 2H, NH2), 8.60 (d, 1H, J = 5.5 Hz). Nuclear magnetic resonance carbon spectrum (13C NMR, 100 MHz, DMSO-d6): δ 114.2, 124.7, 136.6, 157.7, 160.6, 162.4. Fast atom bombardment mass spectrometry (FAB-MS) analysis showed that the molecular ions peaks [M + H]+ had a calculated value of 185.9887, and the measured values were 185.9895 (35Cl ) and 187.9861 (37Cl), consistent with the molecular formula C6H4ClN3S.
References
[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 7, p. 2113 - 2122
4-AMINO-2-CHLOROTHIENO[3,2-D]PYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-AMINO-2-CHLOROTHIENO[3,2-D]PYRIMIDINE manufacturers
- Product
- 4-AMINO-2-CHLOROTHIENO[3,2-D]PYRIMIDINE 16234-40-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-13