ChemicalBook > CAS DataBase List > 3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-

3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-

Application

Product Name: 3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-
CAS No.: 342417-01-0
Chemical Name: 3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-
Synonyms: 6-(4-METHYLPIPERAZIN-1-YL)-4-O-TOLYLNICOTINAMIDE;Netupitant int5;Netupitant Impurity 25;4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-;6-(4-Methyl-1-piperazinyl)-4-(o-tolyl)nicotinamide;α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic acid;6-(4-Methylpiperazin-1-yl)-4-(2-methylphenyl)nicotinamide;6-(4-Methylpiperazine-1-base)-4-(2-Methylphenyl)Niacinamide;6- (4-methylpiperazine 1-yl) -4- (2-methylphenyl) nicotinamide;4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridine-3-carb...
CBNumber: CB22456456
Molecular Formula: C18H22N4O
Formula Weight: 310.39
MOL File: 342417-01-0.mol

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3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)- Property

Melting point:: 164-165℃
Boiling point:: 498.1±45.0 °C(Predicted)
Density: 1.165
storage temp.: 2-8°C
pka: 15.82±0.50(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C18H22N4O/c1-13-5-3-4-6-14(13)15-11-17(20-12-16(15)18(19)23)22-9-7-21(2)8-10-22/h3-6,11-12H,7-10H2,1-2H3,(H2,19,23)
InChIKey: UQTDFKWGXOVHFZ-UHFFFAOYSA-N
SMILES: C1=NC(N2CCN(C)CC2)=CC(C2=CC=CC=C2C)=C1C(N)=O
CAS DataBase Reference: 342417-01-0

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M220158
Product name: 4-(2-Methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinecarboxamide
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: 8514CS
Product name: 6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide
Packaging: 100mg
Price: $70
Updated: 2021/12/16

AK Scientific

Product number: 8514CS
Product name: 6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide
Packaging: 250mg
Price: $73
Updated: 2021/12/16

Chemenu

Product number: CM169151
Product name: 6-(4-methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide
Purity: 95%
Packaging: 1g
Price: $102
Updated: 2021/12/16

Ambeed

Product number: A110317
Product name: 6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide
Purity: 95+%
Packaging: 25g
Price: $152
Updated: 2021/12/16

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3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)- Chemical Properties,Usage,Production

Application

Netupitant is a selective antagonist of the human substance P/neurokine 1 (NK1) receptor. Panostron is a 5-HT3 receptor antagonist with a strong binding affinity for this receptor and low or no affinity for other receptors. 6-(4-methylpiperazin-1-yl)-4-(2-methylphenyl)nicotinamide is an organic synthesis intermediate and pharmaceutical intermediate used in laboratory research and development processes and chemical and pharmaceutical synthesis, primarily as an intermediate for netupitant.

Synthesis

109-01-3

342417-00-9

342417-01-0

Step 3: 1.0 g (4.05 mmol) of 6-chloro-4-o-tolylnicotinamide was dissolved in 9.0 mL of N-methylpiperazine, heated to 100 °C and the reaction was maintained for 2 hours. Upon completion of the reaction, the excess N-methylpiperazine was removed by high vacuum distillation. The residue was purified by silica gel column chromatography using dichloromethane as eluent to give 1.2 g (95% yield) of the target compound, 6-(4-methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide, the product was a pale yellow crystalline foam. Mass spectrometry (ISP): m/z 311 ([M+H]+, 100%), 254 (62%).

References

[1] Patent: US8426450, 2013, B1. Location in patent: Page/Page column 25
[2] Patent: US9403772, 2016, B2. Location in patent: Page/Page column 30
[3] Journal of Organic Chemistry, 2006, vol. 71, # 5, p. 2000 - 2008
[4] Patent: JP2015/17121, 2015, A. Location in patent: Paragraph 0153

3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)- Preparation Products And Raw materials

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View Lastest Price from 3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)- manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)- 342417-01-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-19

Changzhou Rokechem Technology Co., Ltd.

Product: 6-(4-Methylpiperazin-1-yl)-4-(2- methylphenyl)nicotinamide 342417-01-0
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99%; USP/EP/CP
Supply Ability: 1-10000kgs
Release date: 2023-06-08

Career Henan Chemical Co

Product: 6-(4-METHYLPIPERAZIN-1-YL)-4-O-TOLYLNICOTINAMIDE 342417-01-0
Price: US $100.00/KG
Min. Order: 100G
Purity: 98%
Supply Ability: 500KG
Release date: 2018-07-24

342417-01-0, 3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-Related Search:

2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide Methyl (6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbaMate 3-PYRIDINAMINE, N-METHYL-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)- N-tert-butyl-6-chloro-4-(o-tolyl)nicotinamide 3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)- 6-(DIMETHYLAMINO)-4-METHYLNICOTINALDEHYDE 3-PYRIDINECARBOXAMIDE, N-(1,1-DIMETHYLETHYL)-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)- N-METHYL-6-(4-METHYL-PIPERAZIN-1-YL)-4-O-TOLYL-NICOTINAMIDE

6-(4-METHYLPIPERAZIN-1-YL)-4-O-TOLYLNICOTINAMIDE

4-(2-Methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinecarboxamide

6-(4-Methylpiperazin-1-yl)-4-(2-methylphenyl)nicotinamide

3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-

4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridine-3-carboxamide

3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-C32

4-(2-methylphenyl)-6-(4-methylpiperazinyl)-3-pyridinecarboxamide

Netupitant int5

6-(4-Methyl-1-piperazinyl)-4-(o-tolyl)nicotinamide

4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridine-3-carb...

4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-

6(4methylpiperazin1yl)4otolylnicotinamide,6 (4 methylpiperazin 1 yl) 4 o tolylnicotinamide

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic acid

Netupitant Impurity 25

6- (4-methylpiperazine 1-yl) -4- (2-methylphenyl) nicotinamide

6-(4-methylpiperazin-1-yl)-4-o-tolylnicotinamide, 10 mM in DMSO

6-(4-Methylpiperazine-1-base)-4-(2-Methylphenyl)Niacinamide

342417-01-0