ChemicalBook > CAS DataBase List > 4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE

4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE

Product Name
4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE
CAS No.
105806-13-1
Chemical Name
4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE
Synonyms
2-Methyl-4,6-dichloro-5-fluoropyrimidine;4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE;PyriMidine, 4,6-dichloro-5-fluoro-2-Methyl-;4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE ISO 9001：2015 REACH
CBNumber
CB22457529
Molecular Formula
C5H3Cl2FN2
Formula Weight
181
MOL File
105806-13-1.mol
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4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE Property

Boiling point:
221℃
Density 
1.504
Flash point:
87℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-4.96±0.39(Predicted)
Appearance
Off-white to light green Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D437163
Product name
4,6-Dichloro-5-fluoro-2-methylpyrimidine
Packaging
25mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
059863
Product name
4,6-Dichloro-5-fluoro-2-methylpyrimidine
Purity
>96%
Packaging
500mg
Price
$42
Updated
2021/12/16
Apolloscientific
Product number
PC201014
Product name
4,6-Dichloro-5-fluoro-2-methylpyrimidine
Purity
97%
Packaging
1g
Price
$46
Updated
2021/12/16
Matrix Scientific
Product number
059863
Product name
4,6-Dichloro-5-fluoro-2-methylpyrimidine
Purity
>96%
Packaging
1g
Price
$65
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-7-A0
Product name
4,6-Dichloro-5-fluoro-2-methylpyrimidine
Purity
97%
Packaging
1g
Price
$74
Updated
2021/12/16
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4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE Chemical Properties,Usage,Production

Synthesis

1598-63-6

105806-13-1

Part B: Synthesis of 4,6-dichloro-5-fluoro-2-methylpyrimidine. 5-Fluoro-4,6-dihydroxy-2-methylpyrimidine (60 g, 0.42 mol) was dissolved in 300 mL of phosphorus oxychloride (POCl3) and reacted at 120 °C for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure until the rate of evaporation of the solvent decreased to less than 1 drop/sec. Care was taken to avoid over-concentration to prevent loss of product due to volatilization. The concentrated crude product was slowly poured into crushed ice and the slurry was stirred for 1 hour and allowed to warm naturally to room temperature. The precipitated yellow solid was collected by filtration, washed with cold water and briefly air dried to a flow-through state. Finally, the solid was thoroughly dried in a desiccator filled with phosphorus pentoxide (P2O5) to give pure 4,6-dichloro-5-fluoro-2-methylpyrimidine (59 g, 79% yield). LCMS analysis showed (M + H)+ peaks located at 181/183.

References

[1] Patent: WO2009/61879, 2009, A1. Location in patent: Page/Page column 61
[2] Patent: WO2013/82388, 2013, A1. Location in patent: Page/Page column 67
[3] Patent: WO2007/75852, 2007, A2. Location in patent: Page/Page column 32
[4] Patent: US2007/197523, 2007, A1. Location in patent: Page/Page column 7
[5] Patent: US4617393, 1986, A

4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE Suppliers

China 75 Germany 1 India 1 Switzerland 2 United Kingdom 1 United States 7 Global 87
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View Lastest Price from 4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE manufacturers

Dideu Industries Group Limited
Product
4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE 105806-13-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-07
Career Henan Chemical Co
Product
4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE 105806-13-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1kg-1000kg
Release date
2020-01-02

105806-13-1, 4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINERelated Search:


  • 4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE
  • 2-Methyl-4,6-dichloro-5-fluoropyrimidine
  • PyriMidine, 4,6-dichloro-5-fluoro-2-Methyl-
  • 4,6-DICHLORO-5-FLUORO-2-METHYLPYRIMIDINE ISO 9001：2015 REACH
  • 105806-13-1
  • Fluorine series