5-BROMOISOQUINOLIN-1(2H)-ONE

Product Name: 5-BROMOISOQUINOLIN-1(2H)-ONE
CAS No.: 190777-77-6
Chemical Name: 5-BROMOISOQUINOLIN-1(2H)-ONE
Synonyms: 5-bromoisoquinolin-1-ol;5-Bromoisoquinolin-1(2H);5-Bromo-1(2H)-isoquinolinone;5-BROMOISOQUINOLIN-1(2H)-ONE;5-Bromo-2H-isoquinolin-1-one;5-Bromoisoquinolin-1(3H)-one;1(2H)-Isoquinolinone, 5-bromo-;5-bromanyl-2H-isoquinolin-1-one;5-bromo-1,2-dihydroisoquinolin-1-one;5-Bromo-1,2-dihydro-1-oxoisoquinoline
CBNumber: CB22460477
Molecular Formula: C9H6BrNO
Formula Weight: 224.05
MOL File: 190777-77-6.mol

More

Less

5-BROMOISOQUINOLIN-1(2H)-ONE Property

Boiling point:: 443.2±45.0 °C(Predicted)
Density: 1.620
storage temp.: Sealed in dry,Room Temperature
pka: 12.19±0.20(Predicted)
form: solid
color: Light yellow to light brown
InChI: InChI=1S/C9H6BrNO/c10-8-3-1-2-7-6(8)4-5-11-9(7)12/h1-5H,(H,11,12)
InChIKey: UKIWLFJYNMJPEG-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C(Br)=CC=C2)C=CN1

More

Less

Safety

HS Code: 2933499090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P309+P311IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B292600
Product name: 5-Bromoisoquinolin-1(2H)-one
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141874
Product name: 5-Bromoisoquinolin-1-ol
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141874
Product name: 5-Bromoisoquinolin-1-ol
Packaging: 1g
Price: $393.75
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 35616
Product name: 5-Bromoisoquinolin-1(2H)-one
Purity: 95+%
Packaging: 250mg
Price: $412
Updated: 2021/12/16

AK Scientific

Product number: Y5327
Product name: 5-Bromoisoquinolin-1-ol
Packaging: 250mg
Price: $130
Updated: 2021/12/16

More

Less

5-BROMOISOQUINOLIN-1(2H)-ONE Chemical Properties,Usage,Production

Synthesis

1109230-25-2

190777-77-6

5-Bromo-3,4-dihydroisoquinolin-1(2H)-one (4.3 g, 18.9 mmol) and 2,3-dicyano-5,6-dichloro-1,4-benzoquinone (8.6 g, 37.9 mmol) were mixed in 1,4-dioxane (76 mL). The reaction mixture was stirred at 100 °C for 24 hours. Upon completion of the reaction, the solvent was removed by evaporation and the residue was dissolved in ethyl acetate (500 mL) and washed with 10% aqueous sodium hydroxide solution (2 x 500 mL). The organic and aqueous layers were separated and the aqueous layer was further extracted with ethyl acetate (4 x 300 mL). All organic layers were combined and dried with anhydrous sodium sulfate, then concentrated by evaporation. The product was purified by fast chromatography with the eluent being a solvent mixture of dichloromethane and methanol (ratio tapered from 99:1 to 96:4) to afford 5-bromoisoquinolin-1(2H)-one (1.49 g, 6.65 mmol, 35% yield) as a yellow solid. The product was analyzed by LCMS showing a purity of 94% with a retention time (Rt) of 1.243 min, and electrospray mass spectrometry (ESMS) showed a molecular ion peak m/z of 224 ([M+H]+).

References

[1] Patent: WO2014/153055, 2014, A2. Location in patent: Paragraph 0120-0121
[2] Patent: WO2015/20553, 2015, A1. Location in patent: Paragraph 00113-00114
[3] Patent: WO2015/50471, 2015, A1. Location in patent: Paragraph 00107; 00108
[4] Patent: WO2015/50472, 2015, A1. Location in patent: Paragraph 00111; 00112

5-BROMOISOQUINOLIN-1(2H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

5-BROMOISOQUINOLIN-1(2H)-ONE Suppliers

China 110 India 2 United Kingdom 2 United States 8 Global 122

Awesome （Beijing）TechnologyCo.,Ltd.

Tel: 18201687790 18201687790
Fax: QQ：1103319299
Email: yunbo12291229@163.com
Country: China
ProdList: 175
Advantage: 58

Shanghai Na Qian Chemical Technology Co. Ltd.

Tel: 13598610367
Fax: QQ:2468833170
Email: 2841375912@qq.com
Country: China
ProdList: 2786
Advantage: 52

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

ZEROSCHEM.CO.,LTD.

Tel: 10-61256048 13810278579
Fax: +86 10 61256049
Email: sales@zeroschem.com
Country: China
ProdList: 1370
Advantage: 59

Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
Country: China
ProdList: 4267
Advantage: 65

Record Tech (Shanghai) Co., LTD

Tel: 13761627472
Fax: 86-21-64965863
Email: 183009664@qq.com
Country: China
ProdList: 649
Advantage: 62

Tongchuang Pharma(Suzhou). Co., Ltd.

Tel: 0512-63263366 18912765016
Fax: 0512-6326 3366
Email: tongtf110@sina.com
Country: China
ProdList: 993
Advantage: 62

Shanghai Synthfine Chemical Co.,Ltd

Tel: 15921303235
Fax: QQ489466966
Email: sales@synthfine.com
Country: China
ProdList: 1043
Advantage: 58

Wuhan TCASChem Technology Co., Ltd.

Tel: 027-86697669 13986148687
Fax: 86-027-86697669
Email: sales@tcaschem.com
Country: China
ProdList: 3993
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

More

Less

View Lastest Price from 5-BROMOISOQUINOLIN-1(2H)-ONE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 5-BROMOISOQUINOLIN-1(2H)-ONE 190777-77-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

Career Henan Chemical Co

Product: 5-BROMOISOQUINOLIN-1(2H)-ONE 190777-77-6
Price: US $5.50/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1kg-100kg
Release date: 2020-01-08

190777-77-6, 5-BROMOISOQUINOLIN-1(2H)-ONERelated Search:

5-Bromoindole-3-carboxaldehyde 5-Bromo-1,2,3,4-tetrahydro-[1,7]naphthyridine 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 5-broMo- 5-BroMo-4-azaindole-3-carbaldehyde 5-BroMo-1H-pyrrole-2-carboxylic acid 1,2-BENZISOXAZOLE, 5-BROMO- 5-Bromo-1-(2methoxyethyl)-1H-indazole METHYL 4,5-DIBROMO-1H-PYRROLE-2-CARBOXYLATE METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE 5-BROMO-1H-PYRROLO[3,2-B] PYRIDINE 5-BroMo-[1,2,4]triazolo[4,3-a]pyrazine 5-bromo-1H,2H,3H-pyrrolo[3,2-b]pyridin-2-one 5-BroMo[1,2,4]triazolo[1,5-a]pyrazine 5-BROMO-1H-INDOL-3-METHYLAMINE 5-BROMO-1H-INDAZOL-3-AMINE 5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID

5-BROMOISOQUINOLIN-1(2H)-ONE

5-Bromo-1(2H)-isoquinolinone

5-bromoisoquinolin-1-ol

5-Bromo-1,2-dihydro-1-oxoisoquinoline

5-Bromo-2H-isoquinolin-1-one

5-Bromoisoquinolin-1(2H)

5-bromanyl-2H-isoquinolin-1-one

5-bromo-1,2-dihydroisoquinolin-1-one

1(2H)-Isoquinolinone, 5-bromo-

5-Bromoisoquinolin-1(3H)-one

190777-77-6