(R)-3-Amino-1-methyl-piperidine
- Product Name
- (R)-3-Amino-1-methyl-piperidine
- CAS No.
- 1001353-92-9
- Chemical Name
- (R)-3-Amino-1-methyl-piperidine
- Synonyms
- (R)-1-Methylpiperidin-3-amine;(3R)-1-Methylpiperidin-3-amine;(R)-3-AMino-1-Methyl-pipe...;(R)-1-Methyl-3-aminopiperidine;(R)-3-Amino-1-methyl-piperidine;3-Piperidinamine, 1-methyl-, (3R)-;(R)-1-Methylpiperidin-3-aMine dihydrochloride
- CBNumber
- CB22462259
- Molecular Formula
- C6H14N2
- Formula Weight
- 114.19
- MOL File
- 1001353-92-9.mol
(R)-3-Amino-1-methyl-piperidine Property
- Boiling point:
- 136.5±8.0 °C(Predicted)
- Density
- 0.912±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 10.40±0.20(Predicted)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C6H14N2/c1-8-4-2-3-6(7)5-8/h6H,2-5,7H2,1H3/t6-/m1/s1
- InChIKey
- QZSACHHNFDNCNB-ZCFIWIBFSA-N
- SMILES
- N1(C)CCC[C@@H](N)C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P363Wash contaminated clothing before reuse.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 3H32-1-R0
- Product name
- (R)-3-Amino-1-methylpiperidine
- Packaging
- 1g
- Price
- $403
- Updated
- 2021/12/16
- Product number
- 112201
- Product name
- (R)-3-Amino-1-methyl-piperidine
- Packaging
- 1g
- Price
- $564
- Updated
- 2021/12/16
- Product number
- 3H32-1-R0
- Product name
- (R)-3-Amino-1-methylpiperidine
- Packaging
- 250mg
- Price
- $199
- Updated
- 2021/12/16
- Product number
- AS12430-A
- Product name
- (R)-3-Amino-1-methylpiperidine
- Purity
- 97% ee
- Packaging
- 1g
- Price
- $270
- Updated
- 2021/12/16
- Product number
- AS12430-A
- Product name
- (R)-3-Amino-1-methylpiperidine
- Purity
- 97% ee
- Packaging
- 5G
- Price
- $812
- Updated
- 2021/12/16
(R)-3-Amino-1-methyl-piperidine Chemical Properties,Usage,Production
Uses
(3R)-1-Methyl-3-piperidinamine is used in preparation of Ph benzoimidazole derivatives as antitumor agents.
Synthesis
309956-78-3
1001353-92-9
The general procedure for the synthesis of 1-methyl-(R)-3-aminopiperidine from (R)-3-Boc-aminopiperidine was as follows: 1. sodium cyanoborohydride (4.51 g, 0.075 mol) was added batchwise to a mixture of tert-butyl (R)-piperidin-3-ylcarbamate (10 g, 0.05 mol), 30% aqueous formaldehyde (7.5 mL) and methanol (75 mL) at 0 °C. 2. The reaction mixture was stirred at room temperature overnight followed by vacuum concentration. 3. The residue was dissolved in a solvent mixture of ethyl acetate and water. After extraction, the organic layer was washed sequentially with water and brine and dried with anhydrous sodium sulfate. 4. Vacuum concentrating the organic layer to obtain the N-methyl compound as an oil, which can be used in the next reaction without further purification. 5. The above crude product was dissolved in methanol (60 mL) and 4N HCl in dioxane solution (10 mL) was added. 6. The reaction mixture was stirred at room temperature for 6 hours, followed by vacuum concentration. 7. The residue was ground with ether, and the resulting precipitate was filtered and washed with ice-cold methanol to yield 1-methyl-(R)-3-aminopiperidine as a solid (4.01 g, 72% yield). 1H NMR (CD3OD, 400 MHz) δ 3.54 (1H, m), 2.81 (1H, m), 2.62 (1H, m), 2.23 (3H, s), 1.97 (1H, m), 1.67-1.87 (3H, m), 1.56-1.61 (1H, m), 1.41 (9H, s), 1.15-1.42 (1H , m).
References
[1] Patent: US2008/9497, 2008, A1. Location in patent: Page/Page column 72
(R)-3-Amino-1-methyl-piperidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-3-Amino-1-methyl-piperidine manufacturers
- Product
- (R)-3-Amino-1-methyl-piperidine 1001353-92-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minNMR
- Supply Ability
- 50kg/month
- Release date
- 2021-12-25