SELICICLIB

Product Name: SELICICLIB
CAS No.: 186692-44-4
Chemical Name: SELICICLIB
Synonyms: (+/-)-ROSCOVITINE;(Rac)-Roscovitine;2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol;2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-Butanol;1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-
CBNumber: CB22463665
Molecular Formula: C19H26N6O
Formula Weight: 354.45
MOL File: 186692-44-4.mol

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SELICICLIB Property

Boiling point:: 577.5±60.0 °C(Predicted)
Density: 1.25
pka: 14.56±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: KIN0002581
Product name: SELICICLIB
Purity: 95.00%
Packaging: 10MG
Price: $817.39
Updated: 2021/12/16

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SELICICLIB Chemical Properties,Usage,Production

Uses

(Rac)-Roscovitine ((Rac)-Seliciclib) is a selective cyclin-dependent kinases (CDKs) inhibitor. (Rac)-Roscovitine binds to the active sites of CDKs competitively with ATP, inhibiting the phosphorylation activity of CDKs. (Rac)-Roscovitine induces apoptosis in cancer cells. (Rac)-Roscovitine is promising for research of cancers or other diseases associated with CDK dysregulation, such as neurodegenerative diseases, cardiac disorders, viral and protozoan infections, glomerulonephritis, and chronic inflammation[1].

References

[1] Jorda R, et al. Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity. J Med Chem. 2011 Apr 28;54(8):2980-93.

SELICICLIB Preparation Products And Raw materials

Raw materials

Preparation Products

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SELICICLIB Suppliers

China 20 United States 3 Global 23

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186692-44-4, SELICICLIBRelated Search:

OLOMOUCINE N9-ISOPROPYL-OLOMOUCINE OLOMOUCINE II SELICICLIB Roscovitine

2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-Butanol

(+/-)-ROSCOVITINE

2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol

(Rac)-Roscovitine

1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-

186692-44-4