ChemicalBook > CAS DataBase List > (R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE

(R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE

Product Name
(R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE
CAS No.
874964-22-4
Chemical Name
(R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE
Synonyms
(R)-Methyl pyrrolidine-3-...;(R)-methyl pyrrolidine-3-carboxylate methyl(S)-pyrrolidine-3-carboxylatehydrochloride;1H-Benzimidazole-1-acetonitrile,2,3-dihydro-7-oxo-;(R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE;Methyl (3R)-3-pyrrolidinecarboxylate hydrochloride;methyl (3R)-pyrrolidine-3-carboxylate hydrochloride;R-3-Pyrrolidinecarboxylic acid Methyl ester hydrochloride;(3R)-3-Pyrrolidinecarboxylic acid methyl ester hydrochloride;3-Pyrrolidinecarboxylic acid, Methyl ester, hydrochloride, (3R)-
CBNumber
CB22465568
Molecular Formula
C6H12ClNO2
Formula Weight
165.62
MOL File
874964-22-4.mol
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(R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
Appearance
Off-white to light yellow Solid
optical activity
Consistent with structure
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M324825
Product name
(R)-MethylPyrrolidine-3-carboxylateHydrochloride
Packaging
500mg
Price
$210
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0033044
Product name
(R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE
Purity
95.00%
Packaging
250MG
Price
$218.4
Updated
2021/12/16
Activate Scientific
Product number
AS17032-B
Product name
(R)-Methyl pyrrolidine-3-carboxylate HCl
Purity
97% ee
Packaging
1g
Price
$242
Updated
2021/12/16
SynQuest Laboratories
Product number
4H57-5-R2
Product name
Methyl (3R)-pyrrolidine-3-carboxylate hydrochloride
Packaging
1g
Price
$249
Updated
2021/12/16
ChemScene
Product number
CS-B0685
Product name
(R)-methylpyrrolidine-3-carboxylatehydrochloride
Purity
≥97.0%
Packaging
5g
Price
$445
Updated
2021/12/16
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(R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

(R)-Methyl Pyrrolidine-3-carboxylate Hydrochloride acts as a reagent for the synthesis of kinase inhibitor (ERK1/2).

Synthesis

67-56-1

72925-16-7

874964-22-4

To a stirred solution of (3R)-1-{[(1,1-dimethylethyl)oxy]carbonyl}-3-pyrrolidinecarboxylic acid (1.03 g, 4.8 mmol) in methanol (25 mL) was added thionyl chloride (1 mL, 13.7 mmol) dropwise at room temperature under the protection of nitrogen atmosphere. The reaction mixture was heated to reflux for 2 hours and then cooled to room temperature. The reaction mixture was concentrated and the crude product was dissolved in dichloromethane. The solution was further concentrated to give 0.792 g (100% yield) of methyl (3R)-3-pyrrolidine carboxylic acid hydrochloride as an off-white solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 9.93 (m, 2H), 3.74 (s, 3H), 3.58 (br s, 2H), 3.42 (br s, 2H), 3.26 (m, 1H), 2.36-2.25 (m, 2H).

References

[1] Patent: WO2009/5998, 2009, A1. Location in patent: Page/Page column 244

(R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE Suppliers

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View Lastest Price from (R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
(R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE 874964-22-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-09

874964-22-4, (R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDERelated Search:


  • (R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE
  • methyl(S)-pyrrolidine-3-carboxylatehydrochloride
  • (R)-Methyl pyrrolidine-3-...
  • 3-Pyrrolidinecarboxylic acid, Methyl ester, hydrochloride, (3R)-
  • 3-Pyrrolidinecarboxylic acid, Methyl ester, hydrochloride (1:1), (3R)-
  • Methyl (3R)-3-pyrrolidinecarboxylate hydrochloride
  • (3R)-3-Pyrrolidinecarboxylic acid methyl ester hydrochloride
  • R-3-Pyrrolidinecarboxylic acid Methyl ester hydrochloride
  • methyl (3R)-pyrrolidine-3-carboxylate hydrochloride
  • (R)-methyl pyrrolidine-3-carboxylate&nbsp
  • 1H-Benzimidazole-1-acetonitrile,2,3-dihydro-7-oxo-
  • (3R)-3-Pyrrolidinecarboxylic acid methyl ester hydrochloride (1:1)
  • 874964-22-4