ChemicalBook > CAS DataBase List > 3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE

3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE

Product Name: 3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE
CAS No.: 870063-60-8
Chemical Name: 3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE
Synonyms: 3-fluoro-4-Pyridinemethanol;3-Fluoro-4-(hydroxyMethyl...;4-PyridineMethanol, 3-fluoro-;(3-FLUOROPYRIDIN-4-YL)METHANOL;3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE;(3-Fluoro-Pyridin-4-Yl)-Methanol(WX640299)
CBNumber: CB22465720
Molecular Formula: C6H6FNO
Formula Weight: 127.12
MOL File: 870063-60-8.mol

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3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE Property

Melting point:: 83-84 °C
Boiling point:: 221.0±25.0 °C(Predicted)
Density: 1.262±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: solid
pka: 12.71±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: MNO000191
Product name: (3-Fluoropyridin-4-yl)methanol
Packaging: 1g
Price: $179
Updated: 2025/07/31

TRC

Product number: B435033
Product name: (3-Fluoropyridin-4-yl)methanol
Packaging: 100mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H01-3-60
Product name: (3-Fluoropyridin-4-yl)methanol
Packaging: 5G
Price: $87
Updated: 2021/12/16

Matrix Scientific

Product number: 064632
Product name: (3-Fluoropyridin-4-yl)methanol
Purity: 95%
Packaging: 5g
Price: $89
Updated: 2021/12/16

AK Scientific

Product number: J96816
Product name: (3-Fluoropyridin-4-yl)methanol
Packaging: 5g
Price: $90
Updated: 2021/12/16

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3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE Chemical Properties,Usage,Production

Synthesis

372-47-4

68-12-2

870063-60-8

Step 1. Synthesis of (3-fluoropyridin-4-yl)methanol 3-Fluoropyridine (600 g, 6.18 mol) was dissolved in anhydrous THF (6 L) under nitrogen protection, mechanically stirred and cooled to -65 °C. A THF solution of lithium diisopropylamine (3.4 L, 6.5 mol) was slowly added over a period of 2 h. The reaction temperature was kept below -60 °C and stirring was continued for 1 h at this temperature. Subsequently, pure DMF (804 mL, 10.4 mol) was added dropwise over 1 h, the temperature was maintained below -60 °C and the reaction was monitored by TLC until the 3-fluoropyridine was completely consumed. Upon completion of the reaction, the mixture was slowly warmed to -10 °C and water (1.1 Kg, 62 mol) was added. Sodium borohydride (234 g, 6.18 mol) was added in batches at 0 °C and stirred for a few minutes. Next, 6 M HCl (5.6 L) was added slowly over 1 h. The quenching temperature was controlled to be between 0-25°C. The reaction mixture was heated to 40°C and stirred overnight. After cooling to 0-15 °C, the pH was adjusted to 12 by slow addition of 6 M NaOH. the aqueous layer was extracted with isopropyl acetate (500 mL x 1,1L x 3). The organic layers were combined, washed with brine, dried over Na2SO4 and concentrated under reduced pressure. Heptane-isopropyl acetate (1.2L, v/v=5/1) was added to the crude product and the product was stirred at 0°C for 30 min to crystallize. Filtered, the filter cake was washed with cooled heptane (250 mL x 1) and dried under vacuum to give the light yellow solid title compound (688 g, 88% yield). 1H NMR (400 MHz, CDCl3) δ 8.42 (d, J=4.8 Hz, 1H), 8.40 (d, J=1.6 Hz, 1H), 7.49 (t, J=4.8 Hz, 1H), 4.85 (s, 2H), 2.35 (br s, 1H).

References

[1] Patent: WO2016/49048, 2016, A1. Location in patent: Paragraph 0122
[2] Patent: WO2016/100349, 2016, A2. Location in patent: Paragraph 0171

3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE manufacturers

Career Henan Chemical Co

Product: 3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE 870063-60-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500KG
Release date: 2018-08-19

870063-60-8, 3-FLUORO-4-(HYDROXYMETHYL)PYRIDINERelated Search:

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(3-FLUOROPYRIDIN-4-YL)METHANOL

3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE

3-Fluoro-4-(hydroxyMethyl...

4-PyridineMethanol, 3-fluoro-

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(3-Fluoro-Pyridin-4-Yl)-Methanol(WX640299)

870063-60-8