CAY10566

Product Name: CAY10566
CAS No.: 944808-88-2
Chemical Name: CAY10566
Synonyms: CAY10566;CAY10566, 10 mM in DMSO;CAY 10566, SCD1 inhibitor;Inhibitor,inhibit,Stearoyl-CoA Desaturase (SCD),CAY10566,CAY 10566,CAY-10566;2-(6-(4-(2-CHLORO-5-FLUOROPHENOXY)PIPERIDIN-1-YL)PYRIDAZIN-3-YL)-5-METHYL-1,3,4-OXADIAZOLE;3-[4-(2-CHLORO-5-FLUOROPHENOXY)-1-PIPERIDINYL]-6-(5-METHYL-1,3,4-OXADIAZOL-2-YL)-PYRIDAZINE;Pyridazine, 3-[4-(2-chloro-5-fluorophenoxy)-1-piperidinyl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)-
CBNumber: CB22468453
Molecular Formula: C18H17ClFN5O2
Formula Weight: 389.81
MOL File: 944808-88-2.mol

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CAY10566 Property

Melting point:: 160 - 170°C
Boiling point:: 600.2±65.0 °C(Predicted)
Density: 1.369±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 2.01±0.10(Predicted)
form: Solid
color: Pale Beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3223
Product name: CAY10566
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $196.65
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3223
Product name: CAY10566
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $833
Updated: 2025/07/31

Cayman Chemical

Product number: 10012562
Product name: CAY10566
Purity: ≥98%
Packaging: 1mg
Price: $79
Updated: 2024/03/01

Cayman Chemical

Product number: 10012562
Product name: CAY10566
Purity: ≥98%
Packaging: 5mg
Price: $296
Updated: 2024/03/01

Cayman Chemical

Product number: 10012562
Product name: CAY10566
Purity: ≥98%
Packaging: 10mg
Price: $553
Updated: 2024/03/01

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CAY10566 Chemical Properties,Usage,Production

Description

Stearoyl-CoA desaturase (SCD) catalyzes the committed step of the conversion of saturated, long-chain fatty acids to monounsaturated fatty acids. The SCD1 gene is thought to play a key role in lipid homeostasis and body weight regulation. Thus, modulating SCD1 activity pharmacologically may be a useful tool for regulating type 2 diabetes, dyslipidemia, and obesity. CAY10566 is a potent and selective inhibitor of SCD1 that demonstrates IC₅₀ values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. This compound inhibits the conversion of saturated, long-chain fatty acyl-CoAs to monounsaturated, long-chain fatty acyl-CoAs in HepG2 cells with IC₅₀ values of 7.9 and 6.8 nM, respectively, when heptadecanoic acid and palmitic acid are used as the substrate.

Uses

CAY10566, is a stearoyl-CoA desaturase (SCD) inhibitor.

in vivo

After establishment of palpable tumors, the mice are treated with vehicle or SCD1 inhibitor (2.5 mg/kg CAY10566 orally twice daily). The effect of SCD1 inhibition on the Akt-driven tumors is greater than on the Ras-driven tumors, with the mean tumor volume at day 13 or 14 post therapy, relative to untreated tumors, 0.5±0.04 and 0.67±0.05 respectively (P=0.01 for Ras-Akt comparison, by two-tailed t test)^[4].

References

[1] PAUL COHEN. Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss[J]. Science, 2002, 297 5579. DOI: 10.1126/science.1071527
[2] PAWEL DOBRZYN. Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart.[J]. American journal of physiology. Endocrinology and metabolism, 2008: E357-64. DOI: 10.1152/ajpendo.00471.2007
[3] MAKOTO MIYAZAKI. Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis.[J]. Cell metabolism, 2007, 6 6: 484-496. DOI: 10.1016/j.cmet.2007.10.014
[4] GANG LIU. Discovery of Potent, Selective, Orally Bioavailable Stearoyl-CoA Desaturase 1 Inhibitors[J]. Journal of Medicinal Chemistry, 2007, 50 13: 3086-3100. DOI: 10.1021/jm070219p
[5] BENJAMIN M VINCENT. Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity.[J]. Cell reports, 2018: 2742-2754.e31. DOI: 10.1016/j.celrep.2018.11.028
[6] JUNMEI YI. Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2020: 31189-31197. DOI: 10.1073/pnas.2017152117
[7] LESLIE MAGTANONG . Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State[J]. Cell Chemical Biology, 2019, 26 3: Pages 420-432.e9. DOI: 10.1016/j.chembiol.2018.11.016

CAY10566 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10566 Suppliers

China 63 United States 8 Global 71

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

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944808-88-2, CAY10566Related Search:

2-(6-(4-(2-CHLORO-5-FLUOROPHENOXY)PIPERIDIN-1-YL)PYRIDAZIN-3-YL)-5-METHYL-1,3,4-OXADIAZOLE

3-[4-(2-CHLORO-5-FLUOROPHENOXY)-1-PIPERIDINYL]-6-(5-METHYL-1,3,4-OXADIAZOL-2-YL)-PYRIDAZINE

CAY10566

Pyridazine, 3-[4-(2-chloro-5-fluorophenoxy)-1-piperidinyl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)-

Inhibitor,inhibit,Stearoyl-CoA Desaturase (SCD),CAY10566,CAY 10566,CAY-10566

CAY 10566, SCD1 inhibitor

CAY10566, 10 mM in DMSO

944808-88-2

C18H17ClFN5O2