CAY10566

ChemicalBook > CAS DataBase List > CAY10566

Product Name: CAY10566
CAS No.: 944808-88-2
Chemical Name: CAY10566
Synonyms: CAY10566;Inhibitor,inhibit,Stearoyl-CoA Desaturase (SCD),CAY10566,CAY 10566,CAY-10566;2-(6-(4-(2-CHLORO-5-FLUOROPHENOXY)PIPERIDIN-1-YL)PYRIDAZIN-3-YL)-5-METHYL-1,3,4-OXADIAZOLE;3-[4-(2-CHLORO-5-FLUOROPHENOXY)-1-PIPERIDINYL]-6-(5-METHYL-1,3,4-OXADIAZOL-2-YL)-PYRIDAZINE;Pyridazine, 3-[4-(2-chloro-5-fluorophenoxy)-1-piperidinyl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)-
CBNumber: CB22468453
Molecular Formula: C18H17ClFN5O2
Formula Weight: 389.81
MOL File: 944808-88-2.mol

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CAY10566 Property

Melting point:: 160 - 170°C
Boiling point:: 600.2±65.0 °C(Predicted)
Density: 1.369±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 2.01±0.10(Predicted)
form: Solid
color: Pale Beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3223
Product name: CAY10566
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $201
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3223
Product name: CAY10566
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $810
Updated: 2024/03/01

Cayman Chemical

Product number: 10012562
Product name: CAY10566
Purity: ≥98%
Packaging: 1mg
Price: $79
Updated: 2024/03/01

Cayman Chemical

Product number: 10012562
Product name: CAY10566
Purity: ≥98%
Packaging: 5mg
Price: $296
Updated: 2024/03/01

Cayman Chemical

Product number: 10012562
Product name: CAY10566
Purity: ≥98%
Packaging: 10mg
Price: $553
Updated: 2024/03/01

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CAY10566 Chemical Properties,Usage,Production

Description

Stearoyl-CoA desaturase (SCD) catalyzes the committed step of the conversion of saturated, long-chain fatty acids to monounsaturated fatty acids. The SCD1 gene is thought to play a key role in lipid homeostasis and body weight regulation. Thus, modulating SCD1 activity pharmacologically may be a useful tool for regulating type 2 diabetes, dyslipidemia, and obesity. CAY10566 is a potent and selective inhibitor of SCD1 that demonstrates IC₅₀ values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. This compound inhibits the conversion of saturated, long-chain fatty acyl-CoAs to monounsaturated, long-chain fatty acyl-CoAs in HepG2 cells with IC₅₀ values of 7.9 and 6.8 nM, respectively, when heptadecanoic acid and palmitic acid are used as the substrate.

Uses

CAY10566, is a stearoyl-CoA desaturase (SCD) inhibitor.

CAY10566 Preparation Products And Raw materials

Raw materials

Preparation Products

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944808-88-2, CAY10566Related Search:

2-(6-(4-(2-CHLORO-5-FLUOROPHENOXY)PIPERIDIN-1-YL)PYRIDAZIN-3-YL)-5-METHYL-1,3,4-OXADIAZOLE

3-[4-(2-CHLORO-5-FLUOROPHENOXY)-1-PIPERIDINYL]-6-(5-METHYL-1,3,4-OXADIAZOL-2-YL)-PYRIDAZINE

CAY10566

Pyridazine, 3-[4-(2-chloro-5-fluorophenoxy)-1-piperidinyl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)-

Inhibitor,inhibit,Stearoyl-CoA Desaturase (SCD),CAY10566,CAY 10566,CAY-10566

944808-88-2

C18H17ClFN5O2