2-BROMO-5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE

Product Name: 2-BROMO-5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE
CAS No.: 960289-03-6
Chemical Name: 2-BROMO-5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE
Synonyms: 2-Bromo-5,6-dihydrothieno[2,3-c]pyridin-7(4H);2-broMo-4H,5H,6H,7H-thieno[2,3-c]pyridin-7-one;2-BROMO-5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE;2-broMo-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one;Thieno[2,3-c]pyridin-7(4H)-one, 2-bromo-5,6-dihydro-;2-Bromo-5,6-dihydrothieno[2,3-c]pyridin-7(4h)-oneone;2-Bromo-7-oxo-4,5,6,7-tetrahydrothieno[2,3-c]pyridine;2-Bromo-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one,tech
CBNumber: CB22468998
Molecular Formula: C7H6BrNOS
Formula Weight: 232.1
MOL File: 960289-03-6.mol

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2-BROMO-5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE Property

Boiling point:: 471.8±45.0 °C(Predicted)
Density: 1.726±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 13.97±0.20(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B691428
Product name: 2-Bromo-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one
Packaging: 25mg
Price: $170
Updated: 2021/12/16

AK Scientific

Product number: Y5686
Product name: 2-Bromo-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one
Packaging: 100mg
Price: $210
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H70-9-Y3
Product name: 2-Bromo-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one
Packaging: 1g
Price: $1376
Updated: 2021/12/16

Matrix Scientific

Product number: 094069
Product name: 2-Bromo-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one
Purity: 95+%
Packaging: 250mg
Price: $1475
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H70-9-Y3
Product name: 2-Bromo-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one
Packaging: 250mg
Price: $496
Updated: 2021/12/16

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2-BROMO-5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE Chemical Properties,Usage,Production

Uses

2-Bromo-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one is an intermediate in preparation of thieno[2,3-c]pyridine derivatives as MCH receptor antagonists.

Synthesis

14470-51-0

960289-03-6

General procedure for the synthesis of 2-bromo-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-ones from 5,6-dihydrothieno[2,3-c]pyridin-7(4H)-ones: 5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one (4.80 g, 31.37 mmol) was dissolved in acetic acid (40 mL) and water (30 mL ) in a solvent mixture. After cooling the reaction mixture to 0°C, bromine (1.8 mL, 34.51 mmol) was added slowly and dropwise. The reaction was continuously stirred at 0°C for 1 hour. After completion of the reaction, the reaction mixture was diluted with 100 mL of water and extracted with ethyl acetate (3 x 100 mL). The organic layers were combined, washed sequentially with 5% sodium sulfite solution (2 × 50 mL) and saturated sodium bicarbonate solution (2 × 100 mL), dried over anhydrous sodium sulfate, filtered and concentrated to afford 6.20 g (85% yield) of the target product 2-bromo-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one. Mass spectral analysis (MS/ESI) m/z (81Br) 233.9 [M+H]+.

References

[1] Patent: WO2007/146759, 2007, A2. Location in patent: Page/Page column 26
[2] Patent: WO2007/146758, 2007, A2. Location in patent: Page/Page column 34
[3] Patent: US2012/225857, 2012, A1. Location in patent: Page/Page column 16

2-BROMO-5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE Suppliers

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960289-03-6, 2-BROMO-5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONERelated Search:

Deltamethrin

2-BROMO-5,6-DIHYDROTHIENO[2,3-C]PYRIDIN-7(4H)-ONE

2-Bromo-5,6-dihydrothieno[2,3-c]pyridin-7(4H)

2-Bromo-7-oxo-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

2-broMo-4H,5H,6H,7H-thieno[2,3-c]pyridin-7-one

2-broMo-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one

2-Bromo-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one,tech

2-Bromo-5,6-dihydrothieno[2,3-c]pyridin-7(4h)-oneone

Thieno[2,3-c]pyridin-7(4H)-one, 2-bromo-5,6-dihydro-

960289-03-6

C7H6BrNOS