Ethyl 5-chloro-3-methyl-isoxazole-4-carboxylate
- Product Name
- Ethyl 5-chloro-3-methyl-isoxazole-4-carboxylate
- CAS No.
- 3356-94-3
- Chemical Name
- Ethyl 5-chloro-3-methyl-isoxazole-4-carboxylate
- Synonyms
- Ethyl 5-chloro-3-methyl-isoxazole-4-carboxylate;ethyl 5-chloro-3-Methyl-1,2-oxazole-4-carboxylate;4-Isoxazolecarboxylic acid, 5-chloro-3-methyl-, ethyl ester
- CBNumber
- CB22470203
- Molecular Formula
- C7H8ClNO3
- Formula Weight
- 189.6
- MOL File
- 3356-94-3.mol
Ethyl 5-chloro-3-methyl-isoxazole-4-carboxylate Property
- Boiling point:
- 57 °C(Press: 0.3 Torr)
- Density
- 1.280±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -5.09±0.50(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E901975
- Product name
- Ethyl5-Chloro-3-methyl-4-isoxazolecarboxylate
- Packaging
- 250mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- E901975
- Product name
- Ethyl5-Chloro-3-methyl-4-isoxazolecarboxylate
- Packaging
- 50mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- E901975
- Product name
- Ethyl5-Chloro-3-methyl-4-isoxazolecarboxylate
- Packaging
- 100mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 073464
- Product name
- Ethyl 5-chloro-3-methylisoxazole-4-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $899
- Updated
- 2021/12/16
- Product number
- W5522
- Product name
- Ethyl5-chloro-3-methyl-isoxazole-4-carboxylate
- Packaging
- 5g
- Price
- $1026
- Updated
- 2021/12/16
Ethyl 5-chloro-3-methyl-isoxazole-4-carboxylate Chemical Properties,Usage,Production
Uses
Ethyl 5-Chloro-3-methyl-4-isoxazolecarboxylate is an intermediate used to prepare (difluorobutenylthio)-substituted heterocyclic or carbocyclic ring compounds as pesticides.
Synthesis
16880-46-9
3356-94-3
General procedure for the synthesis of ethyl 5-chloro-3-methyl-3-isoazole-4-carboxylate from compound (CAS:16880-46-9): to compound 139a (3 g, 17.5 mmol) was added trichlorophosphorus (POCl3, 21.5 g, 140.2 mmol, 13 ml) in a single step. Theophylline (1.8 g, 17.5 mmol) was subsequently added. The reaction mixture was stirred at 110 °C for 24 h under the protection of nitrogen (N2). After completion of the reaction, ice water (15 ml) was added to the mixture to quench the reaction and the aqueous phase was extracted with ethyl acetate (EtOAc, 25 ml x 3). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to give the intermediate compound 139b (brown oil, 2.6 g, 13.7 mmol, yield: 78.2%).1H NMR (400 MHz, CDCl3) δ 4.36 (q, J = 7.1 Hz, 2H), 2.48 (s, 3H). 1.38 (t, J = 7.2Hz, 3H).
References
[1] Patent: WO2018/64119, 2018, A1. Location in patent: Paragraph 0862
Ethyl 5-chloro-3-methyl-isoxazole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 5-chloro-3-methyl-isoxazole-4-carboxylate manufacturers
- Product
- Ethyl 5-chloro-3-methyl-isoxazole-4-carboxylate 3356-94-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-07-18