ChemicalBook > CAS DataBase List > Pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione
Pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione
- Product Name
- Pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione
- CAS No.
- 57489-70-0
- Chemical Name
- Pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione
- Synonyms
- Pyrazolo[1,5-a]pyrimidine-5,7-ol;pyrazolo[1,5-a]pyrimidine-5,7-diol;7-Hydroxy-4H-pyrazolo[1,5-a]pyrimidin-5-one;5-Hydroxy-4H-pyrazolo[1,5-a]pyrimidin-7-one;7-Hydroxypyrazolo[1,5-a]pyrimidin-5(4H)-one;7-hydroxy-1h-pyrazolo[1,5-a]pyrimidin-5-one;Pyrazolo[1,5-a]pyrimidin-5(4H)-one, 7-hydroxy-
- CBNumber
- CB22470218
- Molecular Formula
- C6H5N3O2
- Formula Weight
- 151.12
- MOL File
- 57489-70-0.mol
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Pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione Property
- Melting point:
- 239-240 °C (decomp)
- Boiling point:
- 290.6±40.0 °C(Predicted)
- Density
- 1.74±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 4.50±1.00(Predicted)
- Appearance
- Off-white to light yellow Solid
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Safety
- HS Code
- 2933998090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- P846525
- Product name
- Pyrazolo[1,5-a]pyrimidine-5,7-diol
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR927008
- Product name
- Pyrazolo[1,5-a]pyrimidine-5,7-diol
- Purity
- 96%
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR927008
- Product name
- Pyrazolo[1,5-a]pyrimidine-5,7-diol
- Purity
- 96%
- Packaging
- 5g
- Price
- $310
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CHM0313128
- Product name
- PYRAZOLO[1,5-A]PYRIMIDINE-5,7-DIOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.29
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR927008
- Product name
- Pyrazolo[1,5-a]pyrimidine-5,7-diol
- Purity
- 96%
- Packaging
- 10g
- Price
- $555
- Updated
- 2021/12/16
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Pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione Chemical Properties,Usage,Production
Synthesis
1820-80-0
105-53-3
57489-70-0
Step A - Synthesis of pyrazolo[1,5-a]pyrimidine-5,7-diol (Int-9a): to 1H-pyrazol-3-amine (12.3 g, 148.0 mmol) in 50 mL of deionized water was added diethyl malonate (25.0 mL, 164.7 mmol), followed by the addition of an ethanolic solution of 21 wt% NaOEt (110 mL. 294.6 mmol) and additional ethanol (50 mL). The reaction mixture was heated at 80 °C for 16 h under argon protection. After completion of the reaction, it was cooled to room temperature. The reaction mixture was concentrated to near dryness under reduced pressure and 500 mL of water was added. Dissolution of the solid was promoted by vigorous stirring and the pH was subsequently adjusted to ~2 with hydrochloric acid, at which point a precipitate was generated. The precipitate was collected by vacuum filtration and dried to give pyrazolo[1,5-a]pyrimidine-5,7-diol (Int-9a) as a brown solid (17.13 g, 113.4 mmol, 77% yield).
References
[1] Patent: WO2011/2887, 2011, A1. Location in patent: Page/Page column 86
[2] Patent: WO2012/27234, 2012, A1. Location in patent: Page/Page column 39; 40
[3] Patent: US2011/294781, 2011, A1. Location in patent: Page/Page column 20
[4] Patent: WO2012/27240, 2012, A1. Location in patent: Page/Page column 47
[5] Patent: WO2012/47569, 2012, A1. Location in patent: Page/Page column 41
Pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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