Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate
- Product Name
- Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate
- CAS No.
- 1224944-77-7
- Chemical Name
- Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate
- Synonyms
- Loptinib intermediate;1224944-77-7;5-chloropyrazolo[1,5-a]pyriMidine-3-carboxylate;5-chloropyrazole[1,5-a]pyrimidine-3-ethylformate;thyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate;Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate;Chloropyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl este;Chloropyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester;5-Chloropyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl este;5-Chloro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester
- CBNumber
- CB22471280
- Molecular Formula
- C9H8ClN3O2
- Formula Weight
- 225.63
- MOL File
- 1224944-77-7.mol
Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate Property
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.44±0.40(Predicted)
- Appearance
- white to brown solid
- InChI
- InChI=1S/C9H8ClN3O2/c1-2-15-9(14)6-5-11-13-4-3-7(10)12-8(6)13/h3-5H,2H2,1H3
- InChIKey
- UOZKVCQDLXBWBG-UHFFFAOYSA-N
- SMILES
- C12=C(C(OCC)=O)C=NN1C=CC(Cl)=N2
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E903760
- Product name
- Ethyl5-Chloropyrazolo[1,5-a]pyrimidine-3-carboxylate
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- J94299
- Product name
- Ethyl5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate
- Packaging
- 1g
- Price
- $48
- Updated
- 2021/12/16
- Product number
- X3315
- Product name
- Ethyl5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- J94299
- Product name
- Ethyl5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate
- Packaging
- 5g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- X3315
- Product name
- Ethyl5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate
- Packaging
- 5g
- Price
- $197
- Updated
- 2021/12/16
Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate Chemical Properties,Usage,Production
Uses
Ethyl 5-Chloropyrazolo[1,5-a]pyrimidine-3-carboxylate is used in preparation of antitumor pyrazolopyrimidine compound and it intermediates.
Synthesis
926663-00-5
1224944-77-7
Step B: Preparation of ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate; Ethyl 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate (22.7 g, 110 mmol) was suspended in phosphorus triclosan (100 mL) and heated to reflux. After maintaining the reflux reaction for 2 h, the reaction mixture was cooled and the excess phosphorous trichloride was removed by distillation under reduced pressure. The residue was diluted with dichloromethane (100 mL) and slowly poured into a flask containing ice water. The organic and aqueous layers were separated and the aqueous layer was further extracted with dichloromethane. All organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to give ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate (24.2 g, 97.6% yield) as a light yellow solid. Mass spectrum (APCI) m/z = 225.9 (M + H).
References
[1] Patent: WO2011/6074, 2011, A1. Location in patent: Page/Page column 70-71
[2] Chemical and Pharmaceutical Bulletin, 2017, vol. 65, # 11, p. 1058 - 1077
[3] Patent: WO2012/34095, 2012, A1. Location in patent: Page/Page column 68
[4] Patent: US2016/159808, 2016, A1. Location in patent: Paragraph 1357; 1358; 1381; 1382; 1394; 1395
[5] Patent: TW2016/520, 2016, A. Location in patent: Paragraph 0165
Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate Suppliers
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View Lastest Price from Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate manufacturers
- Product
- Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate 1224944-77-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate 1224944-77-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-20
- Product
- Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate 1224944-77-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-03