(2-Amino-3-chlorophenyl)methanol
- Product Name
- (2-Amino-3-chlorophenyl)methanol
- CAS No.
- 61487-25-0
- Chemical Name
- (2-Amino-3-chlorophenyl)methanol
- Synonyms
- (2-Amino-3-chlorophenyl);2-AMino-3-chlorobenzyl Alcohol;2-Amino-3-chlorobenzenemethanol;(2-Amino-3-chlorophenyl)methanol;Benzenemethanol, 2-amino-3-chloro-
- CBNumber
- CB22471684
- Molecular Formula
- C7H8ClNO
- Formula Weight
- 157.6
- MOL File
- 61487-25-0.mol
(2-Amino-3-chlorophenyl)methanol Property
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Dichloromethane, Ethyl Acetate
- form
- Solid
- color
- Light Brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- A603370
- Product name
- 2-Amino-3-chlorobenzylAlcohol
- Packaging
- 2.5g
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- FA143942
- Product name
- (2-Amino-3-chlorophenyl)methanol
- Packaging
- 500mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FA143942
- Product name
- (2-Amino-3-chlorophenyl)methanol
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- W7373
- Product name
- (2-Amino-3-chlorophenyl)methanol
- Packaging
- 1g
- Price
- $157
- Updated
- 2021/12/16
- Product number
- FA143942
- Product name
- (2-Amino-3-chlorophenyl)methanol
- Packaging
- 2g
- Price
- $209
- Updated
- 2021/12/16
(2-Amino-3-chlorophenyl)methanol Chemical Properties,Usage,Production
Chemical Properties
Light Brown Solid
Uses
(2-Amino-3-chlorophenyl)methanol is a useful reactant in the synthesis of CGRP-receptor antagonists and PI3K inhibitors.
Synthesis
6388-47-2
61487-25-0
The general procedure for the synthesis of (2-amino-3-chlorophenyl)methanol from 2-amino-3-chlorobenzoic acid is as follows: 1. a solution of lithium aluminum hydride (210 mL, 1 M, 210 mmol) in tetrahydrofuran (THF) was cooled to room temperature under nitrogen protection. 2. A solution of 2-amino-3-chlorobenzoic acid (15.0 g, 87.4 mmol) in THF (200 mL) was added slowly for a controlled dosing time of 20 minutes. 3. After the addition was completed, the reaction mixture was continued to be stirred at room temperature for 1.5 hours. 4. The reaction mixture was cooled to 10 °C and water (300 mL) was slowly added to quench the reaction. 5. The resulting suspension was filtered through a diatomaceous earth pad which was well rinsed with ethyl acetate (EtOAc, 1 L). 6. The filtrates were combined, washed with saturated saline (3 × 300 mL), dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford the target product (2-amino-3-chlorophenyl)methanol (2a) (13.0 g, 94% yield). Product characterization: 1H NMR (500 MHz, CDCl3) δ 4.69 (s, 2H), 6.63 (t, J = 5.2 Hz, 1H), 6.97 (d, J = 5.0 Hz, 1H), 7.24 (d, J = 5.0 Hz, 1H).
References
[1] Patent: US2006/211705, 2006, A1. Location in patent: Page/Page column 33
[2] Patent: US2007/219370, 2007, A1. Location in patent: Page/Page column 24; 25
[3] Tetrahedron Letters, 2017, vol. 58, # 40, p. 3795 - 3799
[4] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 19, p. 5810 - 5831
[5] Patent: US2010/29598, 2010, A1. Location in patent: Page/Page column 19-20
(2-Amino-3-chlorophenyl)methanol Preparation Products And Raw materials
Raw materials
Preparation Products
(2-Amino-3-chlorophenyl)methanol Suppliers
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View Lastest Price from (2-Amino-3-chlorophenyl)methanol manufacturers
- Product
- (2-Amino-3-chlorophenyl)methanol 61487-25-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09
- Product
- (2-Amino-3-chlorophenyl)methanol 61487-25-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-19