4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide

ChemicalBook > CAS DataBase List > 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide

4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide

Product Name: 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide
CAS No.: 1032229-33-6
Chemical Name: 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide
Synonyms: A939572;SCD inhibitor;A939572;A-939572;A 939572;SCD1 Inhibitor (DMSO solution);stearoyl-CoA desaturase (SCD) inhibitor;SCD1 Inhibitor, SCD1(stearoyl-CoA desaturase 1) inhibitor;SCD1 Inhibitor (DMSO solution), SCD1(stearoyl-CoA desaturase 1) inhibitor;4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide;4-(2-Chlorophenoxy)-N-(3-(methylcarbamoyl)-phenyl)piperidine-1-carboxamide (A939572)
CBNumber: CB22473855
Molecular Formula: C20H22ClN3O3
Formula Weight: 387.86
MOL File: 1032229-33-6.mol

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4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide Property

Boiling point:: 633.5±55.0 °C(Predicted)
Density: 1.302±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥17.15 mg/mL in DMSO; ≥2.5 mg/mL in EtOH with ultrasonic
form: solid
pka: 13.65±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19123
Product name: A-939572
Purity: ≥98%
Packaging: 5mg
Price: $55
Updated: 2024/03/01

Cayman Chemical

Product number: 19123
Product name: A-939572
Purity: ≥98%
Packaging: 10mg
Price: $105
Updated: 2024/03/01

Cayman Chemical

Product number: 19123
Product name: A-939572
Purity: ≥98%
Packaging: 50mg
Price: $495
Updated: 2024/03/01

Tocris

Product number: 4845
Product name: A939572
Purity: ≥99%(HPLC)
Packaging: 10
Price: $173
Updated: 2021/12/16

Tocris

Product number: 4845
Product name: A939572
Purity: ≥99%(HPLC)
Packaging: 50
Price: $742
Updated: 2021/12/16

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4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide Chemical Properties,Usage,Production

Uses

4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide is a stearoyl-CoA desaturase 1 (SCD1) inhibitor.

Biological Activity

A 939572 is a potent stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC50 = 0.4 nM). Selective for SCD1 over a range of kinases and hERG channels. Inhibits proliferation of squamous cell carcinoma FaDu cells in vitro. Also induces cell death of undifferentiated human embryonic stem cells (ESCs). Orally bioavailable.

storage

Store at +4°C

References

[1] xin z, zhao h, serby m d, et al. discovery of piperidine-aryl urea-based stearoyl-coa desaturase 1 inhibitors. bioorganic & medicinal chemistry letters, 2008, 18(15): 4298-4302.
[2] Low glycaemic diets alter lipid metabolism to influence tumour growth Authors: Lien Et al. Nature 2021;599:302.

4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide manufacturers

Career Henan Chemical Co

Product: 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide 1032229-33-6
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-08

1032229-33-6, 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-PiperidinecarboxamideRelated Search:

A939572;A-939572;A 939572

SCD inhibitor

stearoyl-CoA desaturase (SCD) inhibitor

A939572

4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-Piperidinecarboxamide

4-(2-Chlorophenoxy)-N-(3-(methylcarbamoyl)-phenyl)piperidine-1-carboxamide (A939572)

SCD1 Inhibitor (DMSO solution)

SCD1 Inhibitor (DMSO solution), SCD1(stearoyl-CoA desaturase 1) inhibitor

SCD1 Inhibitor, SCD1(stearoyl-CoA desaturase 1) inhibitor

1032229-33-6