2,5-dichloro-4-methoxypyrimidine
- Product Name
- 2,5-dichloro-4-methoxypyrimidine
- CAS No.
- 5750-74-3
- Chemical Name
- 2,5-dichloro-4-methoxypyrimidine
- Synonyms
- 100065;2,5-dichloro-4-methoxypyrimidine;Pyrimidine, 2,5-dichloro-4-methoxy-
- CBNumber
- CB22474559
- Molecular Formula
- C5H4Cl2N2O
- Formula Weight
- 179
- MOL File
- 5750-74-3.mol
2,5-dichloro-4-methoxypyrimidine Property
- Melting point:
- 52-54℃
- Boiling point:
- 303.7±22.0 °C(Predicted)
- Density
- 1.446±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.35±0.29(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D438488
- Product name
- 2,5-Dichloro-4-methoxypyrimidine
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- D10990
- Product name
- 2,5-Dichloro-4-methoxypyrimidine
- Purity
- 98%
- Packaging
- 5g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- D10990
- Product name
- 2,5-Dichloro-4-methoxypyrimidine
- Purity
- 98%
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- OR932533
- Product name
- 2,5-Dichloro-4-methoxypyrimidine
- Purity
- 97%
- Packaging
- 5g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 071119
- Product name
- 2,5-Dichloro-4-methoxypyrimidine
- Purity
- 97%
- Packaging
- 5g
- Price
- $279
- Updated
- 2021/12/16
2,5-dichloro-4-methoxypyrimidine Chemical Properties,Usage,Production
Synthesis
124-41-4
5750-76-5
5750-74-3
Sodium methanolate (295 mg, 5.45 mmol) was dissolved in methanol (13.6 mL) followed by 2,4,5-trichloropyrimidine (500 mg, 2.73 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was concentrated under reduced pressure. The resulting residue was diluted with ether and washed sequentially with 1:1 aqueous solution of water and saturated aqueous ammonium chloride. The organic layer was dried with magnesium sulfate, filtered and concentrated under reduced pressure. Finally, purification by Combiflash column (eluent: 0-10% diethyl ether/hexane) gave 280 mg (1.56 mmol, 57% yield) of 2,5-dichloro-4-methoxypyrimidine as a white solid.
References
[1] Tetrahedron Letters, 2006, vol. 47, # 26, p. 4415 - 4418
[2] Patent: WO2011/75560, 2011, A1. Location in patent: Page/Page column 57
[3] Patent: WO2012/62783, 2012, A1. Location in patent: Page/Page column 66
[4] Patent: WO2013/79493, 2013, A1. Location in patent: Page/Page column 42-43
[5] Patent: WO2013/79494, 2013, A1. Location in patent: Page/Page column 57-58
2,5-dichloro-4-methoxypyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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