3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
- Product Name
- 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
- CAS No.
- 956010-87-0
- Chemical Name
- 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
- Synonyms
- 3-Trifluomethyl-7-aza-1H-indazloe;3-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridine;3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine;1H-Pyrazolo[3,4-b]pyridine, 3-(trifluoroMethyl)-;3-(trifluoromethyl) -1h-pyrazole and [3, 4-b] pyridine
- CBNumber
- CB22474706
- Molecular Formula
- C7H4F3N3
- Formula Weight
- 187.12
- MOL File
- 956010-87-0.mol
3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine Property
- storage temp.
- 2-8°C
- Appearance
- Light brown to brown Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T797355
- Product name
- 3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 6482AC
- Product name
- 3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
- Packaging
- 250mg
- Price
- $82
- Updated
- 2021/12/16
- Product number
- PC904498
- Product name
- 3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $114
- Updated
- 2021/12/16
- Product number
- 6482AC
- Product name
- 3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
- Packaging
- 5g
- Price
- $296
- Updated
- 2021/12/16
- Product number
- PC904498
- Product name
- 3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
- Purity
- 95%
- Packaging
- 5g
- Price
- $302
- Updated
- 2021/12/16
3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine Chemical Properties,Usage,Production
Synthesis
372-48-5
383-63-1
956010-87-0
3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine (1a) was synthesized as follows: n-butyllithium (2.6 M hexane solution, 87.2 mL) was added slowly and dropwise to a solution of tetrahydrofuran (THF, 300 mL) containing N,N-diisopropylamine (25.0 g) under the protection of nitrogen and the temperature was kept at -5 to 0 °C. Subsequently, a solution of 2-fluoropyridine (25 g) in THF (50 mL) was added dropwise to the reaction system at -78 °C and stirred continuously for 1 hour at this temperature. Next, a THF (50 mL) solution of ethyl trifluoroacetate (47.6 g) was slowly added to the reaction solution at -78 °C and stirring was continued at the same temperature for 1 hour. Upon completion of the reaction, hydrazine monohydrate (41.3 g) was added to the system and the reaction mixture was heated to 60 °C and stirred for 6 hours. Subsequently, water (500 mL) was added and stirring was continued at 100 °C for 30 minutes. At the end of the reaction, the precipitate was collected by filtration and dried under reduced pressure to afford the target compound 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine (1a) (32.8 g, 85% yield) as a white solid. The product was confirmed by 1H-NMR (DMSO-d6) and LRMS (ESI) characterization.
References
[1] Patent: US2012/108589, 2012, A1. Location in patent: Page/Page column 13
[2] Patent: US2010/4235, 2010, A1. Location in patent: Page/Page column 15
[3] Patent: US2010/113507, 2010, A1. Location in patent: Page/Page column 8-9
3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine Suppliers
- Tel
- Please Send Email 18652950785
- Fax
- 025-87193546
- chemweiao@163.com
- Country
- China
- ProdList
- 4378
- Advantage
- 65
- Tel
- 0086-27-81360461
- hustzsy@hotmail.com
- Country
- China
- ProdList
- 52
- Advantage
- 58
- Tel
- 021-24206007 13764915196
- Fax
- 86-021-23027023
- sales@balmxy.com
- Country
- China
- ProdList
- 6874
- Advantage
- 55
- Tel
- 02161555100
- Fax
- -
- Country
- China
- ProdList
- 820
- Advantage
- 58
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 18189674620
- 761137152@qq.com
- Country
- China
- ProdList
- 489
- Advantage
- 55
- Tel
- 21-65679720
- Fax
- 0086-21-5186 1128
- service@speedchemical.com
- Country
- China
- ProdList
- 604
- Advantage
- 55
- Tel
- 028-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 7218
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 13933818572
- Fax
- 0311-82870388
- 1519554262@qq.com
- Country
- China
- ProdList
- 1785
- Advantage
- 58
View Lastest Price from 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine manufacturers
- Product
- 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine 956010-87-0
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2019-12-26