1-Cyclopropylpiperidin-4-one
- Product Name
- 1-Cyclopropylpiperidin-4-one
- CAS No.
- 62813-01-8
- Chemical Name
- 1-Cyclopropylpiperidin-4-one
- Synonyms
- 1-cyclopropy;Carbergoline;1-CYCLOPROPYL-4-PIPERIDONE;1-Cyclopropyl-4-piperidinone;1-cyclopropyl-2-piperidinone;1-CYCLOPROPYL-PIPERIDIN-4-ONE;4-Piperidinone, 1-cyclopropyl-;1-Cyclopropylpiperidin-4-one 95+%;1-CYCLOPROPYLTETRAHYDRO-4(1H)-PYRIDINONE;1-Cyclopropyl-4-oxopiperidine, (4-Oxopiperidin-1-yl)cyclopropane
- CBNumber
- CB2247841
- Molecular Formula
- C8H13NO
- Formula Weight
- 139.19
- MOL File
- 62813-01-8.mol
1-Cyclopropylpiperidin-4-one Property
- Boiling point:
- 55°/2mm
- Density
- 1.151±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- 8.18±0.20(Predicted)
- form
- low melting crystals
- color
- Colourless to light yellow
- InChI
- InChI=1S/C8H13NO/c10-8-3-5-9(6-4-8)7-1-2-7/h7H,1-6H2
- InChIKey
- DTUJRJIWGWTNFQ-UHFFFAOYSA-N
- SMILES
- N1(C2CC2)CCC(=O)CC1
- CAS DataBase Reference
- 62813-01-8(CAS DataBase Reference)
Safety
- RIDADR
- 1993
- HazardClass
- IRRITANT
- PackingGroup
- Ⅲ
- HS Code
- 2914390090
N-Bromosuccinimide Price
- Product number
- C986880
- Product name
- 1-Cyclopropylpiperidin-4-one
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 047918
- Product name
- 1-Cyclopropyltetrahydro-4(1H)-pyridinone
- Purity
- >95%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FC134023
- Product name
- 1-Cyclopropylpiperidin-4-one
- Packaging
- 2g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- U265
- Product name
- 1-Cyclopropyl-4-piperidone
- Packaging
- 1g
- Price
- $71
- Updated
- 2021/12/16
- Product number
- 4H17-1-X5
- Product name
- 1-Cyclopropylpiperidin-4-one
- Packaging
- 5G
- Price
- $92
- Updated
- 2021/12/16
1-Cyclopropylpiperidin-4-one Chemical Properties,Usage,Production
Uses
1-Cyclopropylpiperidin-4-one
Synthesis
49683-17-2
62813-01-8
Step 2: A solution of ethyl 3-[cyclopropyl-(2-ethoxycarbonyl-ethyl)-amino]-propionate (39 mmol) in anhydrous tetrahydrofuran (65 mL) was added slowly and dropwise to a solution of sodium hydride (60% oil dispersion, 58 mmol) in anhydrous tetrahydrofuran (65 mL). Anhydrous ethanol (39 mmol) was then added. The reaction mixture was heated under reflux conditions for 24 hours. Upon completion of the reaction, the reaction solution was neutralized with dilute acetic acid to pH 7 and subsequently partitioned between water and ethyl acetate. The aqueous layer was extracted with ethyl acetate, the organic phases were combined and dried over sodium sulfate. The solvent was removed by concentration under reduced pressure to give 10.2 g of red oily material. This crude product was mixed with 18% w/w hydrochloric acid (130 mL) and heated at reflux for 5 hours. At the end of the reaction, the pH was adjusted to about 12 with sodium hydroxide (about 31 g) and the crude mixture was extracted with ethyl acetate. The organic phases were combined and dried with sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by fractional distillation under reduced pressure (20 mbar) and the fractions with a boiling point of 75 °C (20 mbar) were collected to give 3.6 g (67% yield) of the target product 1-cyclopropyl-piperidin-4-one as a colorless oil. Mass spectrometry (MS) analysis showed m/e: 140.0 (MH+, 100%).
References
[1] Patent: US2006/160855, 2006, A1. Location in patent: Page/Page column 14
[2] Patent: WO2005/123716, 2005, A1. Location in patent: Page/Page column 101
[3] Chemical and Pharmaceutical Bulletin, 1980, vol. 28, # 9, p. 2653 - 2657
1-Cyclopropylpiperidin-4-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Cyclopropylpiperidin-4-one manufacturers
- Product
- 1-Cyclopropylpiperidin-4-one 62813-01-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 85.0-99.8%
- Supply Ability
- 200kgs
- Release date
- 2020-01-10