1H-pyrrolo[2,3-c]pyridine-4-carbonitrile
- Product Name
- 1H-pyrrolo[2,3-c]pyridine-4-carbonitrile
- CAS No.
- 1190319-59-5
- Chemical Name
- 1H-pyrrolo[2,3-c]pyridine-4-carbonitrile
- Synonyms
- 4-Cyano-6-azaindole;6-Azaindole-4-carbonitrile;1H-pyrrolo[2,3-c]pyridine-4-carbonitrile
- CBNumber
- CB22484350
- Molecular Formula
- C8H5N3
- Formula Weight
- 143.15
- MOL File
- 1190319-59-5.mol
1H-pyrrolo[2,3-c]pyridine-4-carbonitrile Property
- Boiling point:
- 380℃
- Density
- 1.33
- Flash point:
- 129℃
- storage temp.
- 2-8°C
- Appearance
- Off-white to light brown Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B529953
- Product name
- 1H-Pyrrolo[2,3-c]pyridine-4-carbonitrile
- Packaging
- 10mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CS-0052496
- Product name
- 1H-Pyrrolo[2,3-c]pyridine-4-carbonitrile
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-0052496
- Product name
- 1H-Pyrrolo[2,3-c]pyridine-4-carbonitrile
- Packaging
- 250mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- CS-0052496
- Product name
- 1H-Pyrrolo[2,3-c]pyridine-4-carbonitrile
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 3H37-1-37
- Product name
- 4-Cyano-6-azaindole
- Packaging
- 250mg
- Price
- $390
- Updated
- 2021/12/16
1H-pyrrolo[2,3-c]pyridine-4-carbonitrile Chemical Properties,Usage,Production
Synthesis
557-21-1
69872-17-9
1190319-59-5
Step 1: In a dry reaction flask, 4-bromo-1H-pyrrolo[2,3-c]pyridine (320 mg, 1.62 mmol), Pd(dppf)Cl2 (131 mg, 0.179 mmol), zinc cyanide (190 mg, 1.62 mmol) and zinc powder (21 mg, 0.324 mmol) were dissolved in DMF (20 mL). The reaction mixture was stirred at 120 °C for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and quenched by adding water (100 mL). The reaction mixture was extracted with ethyl acetate (3 x 50 mL) and the organic layers were combined. The organic layer was concentrated under reduced pressure and the crude product obtained was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (1:1, v/v) to give 232 mg (99.8% yield) of 1H-pyrrolo[2,3-c]pyridine-4-carbonitrile as a yellow solid. Mass spectrum (ESI) m/z: 144.2 [M + 1]+.
References
[1] Patent: WO2013/92940, 2013, A1. Location in patent: Page/Page column 38
[2] Patent: WO2018/11628, 2018, A1. Location in patent: Paragraph 00639
[3] Patent: WO2010/145201, 2010, A1. Location in patent: Page/Page column 25-26
1H-pyrrolo[2,3-c]pyridine-4-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-pyrrolo[2,3-c]pyridine-4-carbonitrile manufacturers
- Product
- 1H-pyrrolo[2,3-c]pyridine-4-carbonitrile 1190319-59-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1lg; 2kg; 5kg; 10kg; 100kg
- Release date
- 2019-08-31