1-(5-bromothiophen-3-yl)ethanone
- Product Name
- 1-(5-bromothiophen-3-yl)ethanone
- CAS No.
- 59227-67-7
- Chemical Name
- 1-(5-bromothiophen-3-yl)ethanone
- Synonyms
- 1-(5-Bromothiophen-3-yl);4-Acetyl-2-bromothiophene;3-Acetyl-5-bromothiophene;1-(5-bromo-3-thienyl)ethanone;Ethanone, 1-(5-bromo-3-thienyl)-;1-(5-bromothiophen-3-yl)ethanone;1-(5-broMothiophen-3-yl)ethan-1-one;1-(5-Bromothiophen-3-yl)ethanone - [B71010]
- CBNumber
- CB22484471
- Molecular Formula
- C6H5BrOS
- Formula Weight
- 205.07
- MOL File
- 59227-67-7.mol
1-(5-bromothiophen-3-yl)ethanone Property
- Melting point:
- 63-64 °C
- Boiling point:
- 130-135 °C(Press: 13 Torr)
- Density
- 1.619±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B699005
- Product name
- 1-(5-Bromothiophen-3-yl)ethanone
- Packaging
- 500mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- B699005
- Product name
- 1-(5-Bromothiophen-3-yl)ethanone
- Packaging
- 1g
- Price
- $470
- Updated
- 2021/12/16
- Product number
- 074324
- Product name
- 1-(5-Bromothiophen-3-yl)ethanone
- Purity
- 95+%
- Packaging
- 1g
- Price
- $700
- Updated
- 2021/12/16
- Product number
- HCH0143867
- Product name
- 1-(5-BROMOTHIOPHEN-3-YL)ETHANONE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $933.24
- Updated
- 2021/12/16
- Product number
- W7213
- Product name
- 1-(5-Bromothiophen-3-yl)ethanone
- Packaging
- 1g
- Price
- $995
- Updated
- 2021/12/16
1-(5-bromothiophen-3-yl)ethanone Chemical Properties,Usage,Production
Uses
1-(5-Bromothiophen-3-yl)ethanone is a useful research chemical for the preparation of acifran analogs as agonists of niacin receptors, GPR109a and GPR109b for the treatment of atherosclerosis.
Synthesis
1468-83-3
59227-67-7
The general procedure for the synthesis of 1-(5-bromothiophen-3-yl)ethanone from 3-acetylthiophene is as follows: to a solution of acetic acid (50 mL) containing 3-acetylthiophene (2.52 g, 20 mmol, 1.0 eq.), sodium acetate (2.46 g, 30 mmol, 1.5 eq.) and bromine (3.2 g, 20 mmol, 1.0 eq.) are added sequentially, the bromine The addition of bromine was controlled to be completed within 30 minutes. The reaction mixture was stirred at room temperature overnight. Subsequently, water (150 mL) was added to the reaction system and stirring was continued for 2 hours. The resulting solid product was collected by filtration, washed sequentially with water (10 mL) and petroleum ether (20 mL), and dried to afford the target compound 1-(5-bromothiophen-3-yl)ethanone (8i-2) as a brown solid (1.52 g, 37% yield).
References
[1] Synthetic Communications, 1981, vol. 11, # 1, p. 29 - 34
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 19, p. 5849 - 5853
[3] Patent: US9138427, 2015, B2. Location in patent: Page/Page column 296
[4] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 11, p. 897 - 902
[5] Patent: US2003/114666, 2003, A1
1-(5-bromothiophen-3-yl)ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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