2-Chloro-5-iodothiophene
- Product Name
- 2-Chloro-5-iodothiophene
- CAS No.
- 28712-49-4
- Chemical Name
- 2-Chloro-5-iodothiophene
- Synonyms
- 2-Chloro-5-iodothiophene;Thiophene, 2-chloro-5-iodo-
- CBNumber
- CB22487528
- Molecular Formula
- C4H2ClIS
- Formula Weight
- 244.48
- MOL File
- 28712-49-4.mol
2-Chloro-5-iodothiophene Property
- Melting point:
- -25--24 °C
- Boiling point:
- 95-96 °C(Press: 14 Torr)
- Density
- 2.164±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- HCH0363552
- Product name
- 2-CHLORO-5-IODOTHIOPHENE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.11
- Updated
- 2021/12/16
- Product number
- 096648
- Product name
- 2-Chloro-5-iodothiophene
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $545
- Updated
- 2021/12/16
- Product number
- 096648
- Product name
- 2-Chloro-5-iodothiophene
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1210
- Updated
- 2021/12/16
- Product number
- A102552
- Product name
- 2-Chloro-5-iodothiophene
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- AS033667
- Product name
- 2-Chloro-5-iodothiophene
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $113
- Updated
- 2021/12/16
2-Chloro-5-iodothiophene Chemical Properties,Usage,Production
Synthesis
3437-95-4
28712-49-4
The general procedure for the synthesis of 2-chloro-5-iodothiophene from 2-iodothiophene is as follows: Example 1: Synthesis of 1-(5-chlorothiophen-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol 1. 2-Iodothiophene (2.5 g, 11.9 mmol) was dissolved in hexane (25 mL) and stirred until completely dissolved. 2. N-chlorosuccinimide (NCS; 1.58 g, 11.9 mmol) was added to the above solution. 3. A catalytic amount of perchloric acid (HClO4) was added and the reaction was stirred continuously for 24 hours (h) at room temperature (RT). 4. Upon completion of the reaction, the reaction mixture was filtered and the filtrate was collected. 5. The filtrate was washed sequentially with water (H2O) and brine and then dried with anhydrous sodium sulfate (Na2SO4). 6. The dried filtrate was concentrated under vacuum to give 2-chloro-5-iodothiophene in liquid form (1.7 g, 6.9 mmol, 58% yield). Product characterization: 1H NMR (200 MHz, CDCl3): δ 7.18 (d, J = 4.2 Hz, 1H), 6.69 (d, J = 4.2 Hz, 1H).
References
[1] Journal of Organic Chemistry, 1993, vol. 58, # 11, p. 3072 - 3075
[2] Patent: US2012/329802, 2012, A1. Location in patent: Page/Page column 18-19
2-Chloro-5-iodothiophene Preparation Products And Raw materials
Raw materials
Preparation Products
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