ChemicalBook > CAS DataBase List > GR 125743

GR 125743

Product Name
GR 125743
CAS No.
148547-33-5
Chemical Name
GR 125743
Synonyms
GR 125743;GR 125743, 10 mM in DMSO;GR 125743, 5-HT1B/1D antagonist;N-(4-Methoxy-3-(4-methylpiperazin-1-yl)phenyl)-3-methyl-4-(pyridin-4-yl)benzamide;Benzamide, N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-3-methyl-4-(4-pyridinyl)-;h5-HT1B,cognitive disorder,h5-HT1D,cardiovascular,GR-125743,GR125743,inhibit,Parkinson's disease,5-HT Receptor,GR 125743,5-hydroxytryptamine Receptor,receptor,Inhibitor,Serotonin Receptor
CBNumber
CB22487573
Molecular Formula
C25H28N4O2
Formula Weight
416.52
MOL File
148547-33-5.mol
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GR 125743 Property

storage temp. 
4°C, protect from light
solubility 
DMSO: 100 mg/mL (240.08 mM)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0081850
Product name
GR125743
Purity
99.78%
Packaging
5mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-0081850
Product name
GR125743
Purity
99.78%
Packaging
10mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0081850
Product name
GR125743
Purity
99.78%
Packaging
50mg
Price
$450
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BRS0000377
Product name
GR-125,743
Purity
95.00%
Packaging
10MG
Price
$694.91
Updated
2021/12/16
DC Chemicals
Product number
025865
Product name
GR-125743
Packaging
001
Price
$600
Updated
2021/12/16
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GR 125743 Chemical Properties,Usage,Production

Uses

GR 125743 is a selective 5-HT1B/1D receptor antagonist, with pKis of 8.85 and 8.31 for wild-type h5-HT1B and wild-type h5-HT1D, respectively. GR 125743 is used for the research of Parkinson's disease and cardiovascular diseases[1][2].

in vivo

GR 125743 (0.3 mg/kg; i.p.) produces significant decreases in extracellular 5-HT in the frontal cortex of the conscious guinea pig[2].

Animal Model:Male Dunkin Hartley guinea-pigs (350-450 g)[2]
Dosage:0.3 mg/kg
Administration:Intraperitoneal injection
Result:Produced significant transient increases in extracellular 5-HT.

IC 50

human 5-HT1B Receptor: 8.85 (pKi); human 5-HT1D Receptor: 8.31 (pKi)

References

[1] T Wurch, et al. Induction of a high-affinity ketanserin binding site at the 5-Hydroxytryptamine(1B) receptor by modification of its carboxy-terminal intracellular portion. Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist. Biochem Pharmacol. 2000 May 1;59(9):1117-21. DOI:10.1016/s0006-2952(99)00416-5
[2] Roberts, C., et al. The role of 5-HT1B/1D receptors in the modulation of 5-hydroxytryptamine levels in the frontal cortex of the conscious guinea pig. European Journal of Pharmacology. 1997 May 12;326(1):23-30. DOI:10.1016/s0014-2999(97)00156-8

GR 125743 Preparation Products And Raw materials

Raw materials

Preparation Products

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GR 125743 Suppliers

China 23 United Kingdom 1 United States 5 Global 29
Ascent Scientific
Tel
4401179829988
Fax
4402030 700 369
Email
customerservice@ascentscientific.co.uk
Country
United Kingdom
ProdList
279
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60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9505
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58
Shanghai Yu Ben Biotechnology Co., Ltd.
Tel
021-61350663 15502154572
Fax
-
Email
1639466865@qq.com
Country
China
ProdList
492
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
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58
Chunchuang (Wuhan) Technology Co., Ltd
Tel
15727060112
Email
yutianchun2007@126.com
Country
China
ProdList
9856
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58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24960
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
6001
Advantage
58

148547-33-5, GR 125743Related Search:


  • GR 125743
  • Benzamide, N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-3-methyl-4-(4-pyridinyl)-
  • h5-HT1B,cognitive disorder,h5-HT1D,cardiovascular,GR-125743,GR125743,inhibit,Parkinson's disease,5-HT Receptor,GR 125743,5-hydroxytryptamine Receptor,receptor,Inhibitor,Serotonin Receptor
  • GR 125743, 5-HT1B/1D antagonist
  • GR 125743, 10 mM in DMSO
  • N-(4-Methoxy-3-(4-methylpiperazin-1-yl)phenyl)-3-methyl-4-(pyridin-4-yl)benzamide
  • 148547-33-5
  • Serotonin