4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
- Product Name
- 4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
- CAS No.
- 108477-18-5
- Chemical Name
- 4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
- Synonyms
- NSC-144303;Ubiquitin Isopeptidase-IN-G5;Ubiquitin Isopeptidase Inhibitor I;G5, Ubiquitin Isopeptidase Inhibitor I;Ubiquitin Isopeptidase Inhibitor I, G5;3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide;tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-t;Ubiquitin Isopeptidase Inhibitor I, G5 (NSC144303);3,5-Bis(4-nitrobenzylidene)tetrahydro-4H-thiopyran-4-one 1,1-dioxide;4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
- CBNumber
- CB22489683
- Molecular Formula
- C19H14N2O7S
- Formula Weight
- 414.39
- MOL File
- 108477-18-5.mol
4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide Property
- Melting point:
- 233.5-234.5 °C
- Boiling point:
- 693.0±55.0 °C(Predicted)
- Density
- 1.541±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C,unstable in solution, ready to use.
- solubility
- ≤15mg/ml in DMSO;1mg/ml in dimethyl formamide
- form
- crystalline solid
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 662125
- Product name
- Ubiquitin Isopeptidase Inhibitor I, G5 - CAS 108477-18-5 - Calbiochem
- Packaging
- 10MG
- Price
- $303
- Updated
- 2024/03/01
- Product number
- 21006
- Product name
- Ubiquitin Isopeptidase Inhibitor I
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 21006
- Product name
- Ubiquitin Isopeptidase Inhibitor I
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $175
- Updated
- 2024/03/01
- Product number
- 21006
- Product name
- Ubiquitin Isopeptidase Inhibitor I
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $360
- Updated
- 2024/03/01
- Product number
- U700503
- Product name
- UbiquitinIsopeptidaseInhibitorI,G5
- Packaging
- 10mg
- Price
- $210
- Updated
- 2021/12/16
4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide Chemical Properties,Usage,Production
Description
Ubiquitin isopeptidase inhibitor I induces caspase activation and apoptosis (IC50 = ~1.7 μM) through a Bcl-2-dependent and apoptosome-independent mitochondrial pathway that selectively inhibits ubiquitin isopeptidase activity (IC50 = ~30 μM). It has also been shown to induce necrosis in apoptosis-resistant DKO cells.
Uses
Ubiquitin Isopeptidase Inhibitor I, G5 is a cell-permeable cross-conjugated unsaturated dienone compound.
in vitro
ubiquitin isopeptidase inhibitor i targeted the ubiquitinproteasome system via inhibiting the ubiquitin isopeptidases. ubiquitin isopeptidase inhibitor i could induce a rather unique apoptotic pathway, including a bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the bh3-only protein noxa, stabilization of the inhibitor of apoptosis antagonist smac, but also the involvement of the death receptor pathway. moreover, the treatment of ubiquitin isopeptidase inhibitor i to cell extracts obtained from e1a cells did not inhibit the proteolytic activity of the proteasome, whereas mg-132 potently inhibited the cleavage of the llvy-amc substrate. in addition, noxa induction by ubiquitin isopeptidase inhibitor i could be inhibited by the specific rnai oligos efficiently. when apoptosis was scored, it was found that down-regulation of noxa was able to inhibit but did not suppress apoptosis and caspase activation in response to ubiquitin isopeptidase inhibitor i treatment [1].
IC 50
~30 μm
storage
Store at -20°C
References
[1] e. aleo, c. j. henderson, a. fontanini, et al. identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. cancer research 66(18), 9235-9244 (2006).
4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide Preparation Products And Raw materials
Raw materials
Preparation Products
4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide Suppliers
- Tel
- 0512-58900862 400-0707518
- Fax
- 0086-512-56765862
- sales@alabiochem.com
- Country
- China
- ProdList
- 995
- Advantage
- 59
- Tel
- 0330-2528181
- Fax
- 0330-2528171
- sales@vdmbio.com
- Country
- United States
- ProdList
- 510
- Advantage
- 64
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 001-619-354-5251
- Fax
- 001-855-855-6087
- sales@alabiotech-e.com
- Country
- United States
- ProdList
- 972
- Advantage
- 60
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12308
- Advantage
- 58
- Tel
- 13761635123
- Fax
- 1014988033@qq
- 1014988033@qq.com
- Country
- China
- ProdList
- 4930
- Advantage
- 55
- Tel
- +86-530-529 6766，+86-15666160102 15666160102
- Fax
- 0530-529 6766
- info@chuangli-chem.com
- Country
- China
- ProdList
- 888
- Advantage
- 55
- Tel
- +86-15542445688
- Fax
- 0086-411-39042693
- sales@alabiochem.com
- Country
- China
- ProdList
- 888
- Advantage
- 58
- Tel
- 0411-39042497
- Fax
- 0411-39042693
- sales@alphabiopharm.com
- Country
- China
- ProdList
- 1951
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9730
- Advantage
- 58
View Lastest Price from 4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide manufacturers
- Product
- 4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide 108477-18-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-23