ChemicalBook > CAS DataBase List > 3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer

3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer

Product Name
3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer
CAS No.
26680-10-4
Chemical Name
3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer
Synonyms
Lactide polymer;RESOMER? R 202 H;RESOMER? R 203 S;RESOMER? R 202 S;RESOMER? R 203 H;RESOMER(R) R 203 S;RESOMER(R) R 202 S;RESOMER(R) R 202 H;RESOMER(R) R 203 H;Resomer R 207 S, Poly(D,L-lactide)
CBNumber
CB22490072
Molecular Formula
C6H8O4
Formula Weight
144.12532
MOL File
26680-10-4.mol
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3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer Property

Melting point:
215 °C
Density 
1.23 g/cm3
Flash point:
113°C
storage temp. 
2-8°C
solubility 
Soluble in dichloromethane, tetrahydrofuran, ethyl acetate, chloroform, hexafluoroisopropanol, and acetone. Insoluble in water.
form 
solid
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Safety

WGK Germany 
nwg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
719943
Product name
Poly(D,L-lactide)
Purity
acid terminated, Mw 18,000-24,000
Packaging
5g
Price
$323
Updated
2024/03/01
Sigma-Aldrich
Product number
769835
Product name
Resomer® R 205 S, Poly(D,L-lactide)
Purity
ester terminated
Packaging
1G
Price
$89.9
Updated
2023/06/20
Sigma-Aldrich
Product number
769835
Product name
Resomer® R 205 S, Poly(D,L-lactide)
Purity
ester terminated
Packaging
5G
Price
$284
Updated
2023/06/20
Sigma-Aldrich
Product number
719943
Product name
Poly(D,L-lactide)
Purity
acid terminated, Mw 18,000-24,000
Packaging
1g
Price
$96.1
Updated
2023/06/20
Sigma-Aldrich
Product number
805734
Product name
Poly(D,L-lactide)
Purity
acid terminated, average Mw 15000
Packaging
5g
Price
$329
Updated
2024/03/01
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3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer Chemical Properties,Usage,Production

Chemical Properties

Poly(DL-lactic acid) is a glassy material, occurring as white to golden-yellow pellets or granules.

Uses

May be used to make drug delivery materials for controlled release.

Definition

ChEBI: Lactide is a member of dioxanes.

Production Methods

Lactic acid is a chiral molecule and has two optically active forms: Llactic acid and D-lactic acid. Poly(DL-lactic acid) is produced from the racemic mixture of lactic acid. Lactic acid is produced either from ethylene (petrochemical pathway) or by bacterial fermentation of D-glucose derived from food stocks. The former pathway involves an oxidation step followed by treatment with hydrogen cyanide and produces only racemic DL-lactic acid. In contrast, lactic acid produced by fermentation occurs mainly as L-lactic acid. Lowmolecular- weight poly-DL-(lactic acid) (500–10 000 Da) is produced directly from lactic acid by condensation. Higher-molecular-weight product is produced by one of two major pathways. The first involves a depolymerization of low-molecular-weight polymer into the cyclic dimer form (lactide) followed by ring-opening polymerization. Alternatively, it can be produced by a direct condensation using azeotropic distillation.

General Description

Resomer? R 207 S, Poly(D,L-lactide) (PDLLA), a biodegradable and biocompatible polymer, can be used for a variety of biological applications. It shows properties like long degradation time, mechanical stiffness and hydrophobicity.

Pharmaceutical Applications

Poly(DL-lactic acid) is used in drug delivery systems in implants, injections, and oral solid dispersions. It is also used as a coating agent.

Safety

Poly(DL-lactic acid) degrades to produce lactic acid, which is considered a well-tolerated nontoxic material. Several in vitro and in vivo studies demonstrated that poly(lactic acid) in general (including poly(DL-lactic acid)) is well tolerated and does not induce a significant immune response.However, some studies have illustrated signs of a mild immune response.The FDA has also reported some rare cases of inflammatory responses in patients treated with cosmetic poly(DL-lactic acid) injections.

storage

Poly(DL-lactic acid) is stable under dry conditions. However, it typically biodegrades over a period of 10–15 months according to the molecular weight. Increasing moisture and temperature enhances biodegradation; the onset of degradation in water at 25°C is 6 months.In contrast to many other biodegradable polymers, poly(DL-lactic acid) degrades through a two-step mechanism. The primary degradation step involves the hydrolysis of the ester bonds independently of microbial activity to produce a low-molecular-weight polymer. When the molecular weight drops below 10 000, microorganisms digest the polymer into carbon dioxide and water. Poly(DL-lactic acid) is more stable than poly(L-lactic acid) or poly(D-lactic acid) alone.Poly(DL-lactic acid) should be stored in a dry inert environment at a temperature of -15°C to -20°C.

Incompatibilities

Incompatible with strong acids or alkaline materials.

Regulatory Status

Included in the FDA Inactive Ingredients Database (IM, powder, for injection, suspension, and lyophilization). Poly(DL-lactic acid) is considered as ‘not hazardous’ according to the European Directive 67/548/EEC. Included in parenteral preparations (prolongedrelease powder for suspension for subcutaneous or intramuscular injection) licensed in the UK.

3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer Preparation Products And Raw materials

Raw materials

Preparation Products

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3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer Suppliers

Sigma-Aldrich
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021-61415566 800-8193336
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sale@enkepharma.com
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China
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Email
sale04@alfachem.cn
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China
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Tel
+86-29-89586680 +86-15129568250
Email
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China
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Zhuoer Chemical Co., Ltd
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26680-10-4, 3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymerRelated Search:


  • 3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer
  • Resomer R 202 H, Poly(D,L-lactide)
  • Resomer R 203 H, Poly(D,L-lactide)
  • Resomer R 207 S, Poly(D,L-lactide)
  • Lactide polymer
  • RESOMER(R) R 203 S
  • RESOMER? R 202 S
  • RESOMER? R 203 S
  • RESOMER? R 202 H
  • Resomer(R) R 202 H, Poly(D,L-lactide) acid terminated, Mw 10,000-18,000
  • Resomer(R) R 202 S, Poly(D,L-lactide) ester terminated, Mw 10,000-18,000
  • Resomer(R) R 203 H, Poly(D,L-lactide) acid terminated, Mw 18,000-24,000
  • Poly(D,L-lactide) acid terminated, average Mw 15000
  • RESOMER(R) R 202 S
  • RESOMER(R) R 202 H
  • RESOMER(R) R 203 H
  • RESOMER? R 203 H
  • Resomer(R) R 207 S, Poly(D,L-lactide)
  • Resomer(R) R 205 S, Poly(D,L-lactide)
  • Resomer(R) R 202 H, Poly(D,L-lactide)
  • Resomer(R) R 203 H, Poly(D,L-lactide)
  • 3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer ISO 9001:2015 REACH
  • 26680-10-4
  • C6H8O4n
  • Biodegradable Polymers
  • Lactide and Glycolide Polymers
  • Materials Science
  • Polymer Science
  • Polymers