6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one

Product Name: 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one
CAS No.: 893441-85-5
Chemical Name: 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one
Synonyms: Oxindole-6-boronic;Oxindole-6-boronic acid, pinacol ester;2-Oxoindoline-6-boronic Acid Pinacol Ester;6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one;6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-indol-2-one;6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one - [T26256];6-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,3-dihydro-indol-2-one;2H-Indol-2-one, 1,3-dihydro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CBNumber: CB22490618
Molecular Formula: C14H18BNO3
Formula Weight: 259.11
MOL File: 893441-85-5.mol

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6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one Property

Density: 1.16±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to yellow Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: T889548
Product name: 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Synthonix

Product number: T26256
Product name: 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one
Purity: 97.0%
Packaging: 250mg
Price: $70
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H60-1-HN
Product name: Oxindole-6-boronic acid, pinacol ester
Purity: 95.0%
Packaging: 1g
Price: $170
Updated: 2021/12/16

Matrix Scientific

Product number: 090841
Product name: 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one
Purity: 95+%
Packaging: 250mg
Price: $227
Updated: 2021/12/16

AK Scientific

Product number: W9225
Product name: 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one
Packaging: 1g
Price: $235
Updated: 2021/12/16

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6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one Chemical Properties,Usage,Production

Uses

6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one is useful for preparation of imidazopyridazines as therapeutic kinase inhibitors.

Synthesis

99365-40-9

73183-34-3

893441-85-5

The general procedure for the synthesis of 2-oxoindoline-6-boronic acid pinacol ester from 6-bromo-2-indolone and bis(pinacolato)diboron (898 mg, 3.54 mmol), potassium acetate (694 mg, 7.07 mmol) and Pd(dppf)Cl2-CH2Cl2 (96.0 mg, 0.118 mmol). The above mixture was dissolved in 1,2-dimethoxyethane (DME, 17 mL). The reaction system was heated and reacted at 80 °C overnight. Upon completion of the reaction, the contents of the four reaction vials were combined, the reaction solution was concentrated and purified by column chromatography (cyclohexane/ethyl acetate as eluent) to afford the target compound, 2-oxoindoline-6-boronic acid pinacol ester, as a white solid (2.27 g, 75% yield, 80% purity). The structure of the product was confirmed by 1H NMR (500 MHz, CDCl3): δ 8.57 (broad single peak, 1H), 7.48 (double peak, J=7.3 Hz, 1H), 7.31 (single peak, 1H), 7.23 (double peak, J=7.3 Hz, 1H), 3.55 (single peak, 2H), 1.33 (single peak, 12H).LC-MS (ESI, m/z) analysis showed that: retention time was 0.5 mm. z) analysis showed retention time Rt = 2.75 min and molecular ion peak m/z = 260 ([M+H]+, HPLC method E).

References

[1] Patent: WO2015/144290, 2015, A1. Location in patent: Page/Page column 85
[2] Patent: WO2015/39172, 2015, A1. Location in patent: Page/Page column 60
[3] Patent: WO2011/15641, 2011, A1. Location in patent: Page/Page column 128
[4] Patent: WO2011/101640, 2011, A1. Location in patent: Page/Page column 106
[5] Patent: WO2008/23161, 2008, A1. Location in patent: Page/Page column 120

6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one Preparation Products And Raw materials

Raw materials

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6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one Suppliers

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View Lastest Price from 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one 893441-85-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one 893441-85-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one 893441-85-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-08

893441-85-5, 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-oneRelated Search:

7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL) INDOLIN-2-ONE

Oxindole-6-boronic acid, pinacol ester

2-Oxoindoline-6-boronic Acid Pinacol Ester

6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-indol-2-one

6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one

6-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,3-dihydro-indol-2-one

2H-Indol-2-one, 1,3-dihydro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

Oxindole-6-boronic

6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one - [T26256]

893441-85-5