Ethyl2,2-difluoro-2-(2-methoxyphenyl)acetate
- Product Name
- Ethyl2,2-difluoro-2-(2-methoxyphenyl)acetate
- CAS No.
- 1150164-80-9
- Chemical Name
- Ethyl2,2-difluoro-2-(2-methoxyphenyl)acetate
- Synonyms
- Ethyl α,α-difluoro-2-methoxybenzeneacetate;Ethyl2,2-difluoro-2-(2-methoxyphenyl)acetate;Difluoro-(2-Methoxy-phenyl)-acetic acid ethyl ester;Benzeneacetic acid, α,α-difluoro-2-methoxy-, ethyl ester
- CBNumber
- CB22490678
- Molecular Formula
- C11H12F2O3
- Formula Weight
- 230.21
- MOL File
- 1150164-80-9.mol
Ethyl2,2-difluoro-2-(2-methoxyphenyl)acetate Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
N-Bromosuccinimide Price
- Product number
- E916583
- Product name
- Ethyl2,2-difluoro-2-(2-methoxyphenyl)acetate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- E916583
- Product name
- Ethyl2,2-difluoro-2-(2-methoxyphenyl)acetate
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- HCH0368685
- Product name
- ETHYL-2,2-DIFLUORO-2-(2-METHOXYPHENYL)ACETATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $289.8
- Updated
- 2021/12/16
- Product number
- 092833
- Product name
- Ethyl 2,2-difluoro-2-(2-methoxyphenyl)acetate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $341
- Updated
- 2021/12/16
- Product number
- Z7593
- Product name
- Ethyl2,2-difluoro-2-(2-methoxyphenyl)acetate
- Packaging
- 5g
- Price
- $537
- Updated
- 2021/12/16
Ethyl2,2-difluoro-2-(2-methoxyphenyl)acetate Chemical Properties,Usage,Production
Uses
Ethyl 2,2-difluoro-2-(2-methoxyphenyl)acetate
Synthesis
529-28-2
667-27-6
1150164-80-9
General method: 2-Iodoanisole (1.0 eq.) and ethyl difluorobromoacetate (1.0 eq.) were sequentially added to a suspension of activated copper powder (2.6 eq.) in DMSO (0.38 M) under nitrogen atmosphere. The reaction mixture was stirred at 60 °C for 12 hours. After completion of the reaction, the mixture was filtered through a Celite pad and washed with ether. The organic phase was washed sequentially with water, saturated ammonium chloride solution (2 times) and brine (2 times), followed by drying with anhydrous magnesium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford the target product ethyl 2,2-difluoro-2-(2-methoxyphenyl)acetate.
References
[1] Synlett, 2016, vol. 27, # 1, p. 25 - 28
[2] Organic Letters, 2013, vol. 15, # 11, p. 2648 - 2651
[3] European Journal of Organic Chemistry, 2016, vol. 2016, # 33, p. 5529 - 5538
[4] European Journal of Organic Chemistry, 2017, vol. 2017, # 40, p. 6052 - 6059
Ethyl2,2-difluoro-2-(2-methoxyphenyl)acetate Preparation Products And Raw materials
Raw materials
Preparation Products
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