ChemicalBook > CAS DataBase List > 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide

3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide

Product Name: 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide
CAS No.: 765317-72-4
Chemical Name: 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide
Synonyms: 6-BenzofuransulfonaMide, 3-(3,5-dibroMo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylaMino)sulfonyl]phenyl]-;3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide;PTP1B-IN-4;PTP1B Inhibitor inhibitor;3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-(4-(N-(thiazol-2-yl)sulfamoyl)phenyl)benzofuran-6-sulfonamide;3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide
CBNumber: CB22499424
Molecular Formula: C26H19Br2N3O7S3
Formula Weight: 741.45
MOL File: 765317-72-4.mol

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3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide Property

Boiling point:: 855.0±75.0 °C(Predicted)
Density: 1.812±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C, protect from light
solubility: Soluble in ethanol and DMSO
pka: 4.47±0.25(Predicted)
form: Solid
color: White to off-white
Sensitive: Light Sensitive

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 539741
Product name: PTP1B Inhibitor - CAS 765317-72-4 - Calbiochem
Purity: PTP1B Inhibitor, CAS 765317-72-4, is a cell-permeable, selective, reversible and non-competitive allosteric inhibitor of PTP1B (IC?? = 4 μM and 8 μM for PTP1B403 and PTP1B298, respectively).
Packaging: 5MG
Price: $297
Updated: 2025/07/31

Cayman Chemical

Product number: 15782
Product name: PTP1B Inhibitor
Purity: ≥98%
Packaging: 500μg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 15782
Product name: PTP1B Inhibitor
Purity: ≥98%
Packaging: 1mg
Price: $112
Updated: 2024/03/01

Cayman Chemical

Product number: 15782
Product name: PTP1B Inhibitor
Purity: ≥98%
Packaging: 5mg
Price: $264
Updated: 2024/03/01

Cayman Chemical

Product number: 15782
Product name: PTP1B Inhibitor
Purity: ≥98%
Packaging: 10mg
Price: $468
Updated: 2024/03/01

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3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide Chemical Properties,Usage,Production

Description

Protein tyrosine phosphatase 1B (PTP1B) has critical roles in cell signaling relevant to diabetes, obesity, and cancer. PTP1B inhibitor is a cell-permeable allosteric inhibitor of PTP1B (IC₅₀s = 4 and 8 μM for 403 and 298 residue PTP1B forms, respectively). It binds reversibly and non-competitively, altering the conformation of the catalytic pocket. PTP1B inhibitor selectively increases the phosphorylation of the insulin receptor, insulin receptor substrate 1, and Akt, mimicking the action of insulin.

Uses

PTP1B Inhibitor is used as a PTP1B inhibitor blocks the activity of the Protein Tyrosine Phosphatase 1B, which is a key factor in the negative regulation of insulin and leptin signaling pathway. Protein tyrosine phosphatase 1B (PTP1B) has critical roles in cell signaling relevant to diabetes, obesity, and cancer.

References

[1] SHENG ZHANG Zhong Y Z. PTP1B as a drug target: recent developments in PTP1B inhibitor discovery.[J]. Drug Discovery Today, 2007, 12 9-10: 373-381. DOI: 10.1016/j.drudis.2007.03.011
[2] TONKS N K. Protein tyrosine phosphatases – from housekeeping enzymes to master regulators of signal transduction[J]. The FEBS journal, 2012, 280 2: 346-378. DOI: 10.1111/febs.12077
[3] CHRISTIAN WIESMANN. Allosteric inhibition of protein tyrosine phosphatase 1B[J]. Nature Structural & Molecular Biology, 2004, 11 8: 730-737. DOI: 10.1038/nsmb803
[4] SHUAI LI. The mechanism of allosteric inhibition of protein tyrosine phosphatase 1B.[J]. ACS Applied Bio Materials, 2014: e97668. DOI: 10.1371/journal.pone.0097668

3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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765317-72-4, 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamideRelated Search:

3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide

6-BenzofuransulfonaMide, 3-(3,5-dibroMo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylaMino)sulfonyl]phenyl]-

3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide

PTP1B-IN-4

PTP1B Inhibitor inhibitor

3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-(4-(N-(thiazol-2-yl)sulfamoyl)phenyl)benzofuran-6-sulfonamide

765317-72-4

C26H19Br2N3O7S3